Block Symposia

B Cell and T Helper Cell Responses During Viral Infections

Chairs

• Pooja Jain, Drexel Univ. Col. of Med.
• Tara Strutt, Univ. of Central Florida

Speakers

• Christopher A. Risley, Univ. of Alabama at Birmingham, T-bet controls the maintenance and differentiation potential of flu-induced effector memory B cells
• Arien Schiepers, Rockefeller Univ., Molecular fate-mapping of serum antibodies reveals the effects of antigenic imprinting on repeated immunization
• Patrick Ilunga Mpingabo, NIAID, NIH, Detection of envelope-dimer epitope-like broadly protective antibodies in dengue-immune children in the Philippines following vaccination and natural infection
• Claire E. Otero, Weill Cornell Med., Rhesus macaque cytomegalovirus deploys viral Fc γ receptors to evade antibody-mediated cellular immunity
• Mirela Kuka, Univ. Vita Salute San Raffaele, Italy, Interferon gamma supresses T follicular helper cell and antibody responses upon viral infection
• Tanushree Dangi, Feinberg Sch. of Med., Northwestern Univ., Pre-existing immunity modulates responses to mRNA boosters
• Valeria Flores Malavet, Univ. of Central Florida, Memory CD4 T cell recall following Influenza A Virus infection is unaltered by the pregnancy environment
• Tineke Cantaert, Inst. Pasteur du Cambodge, Cambodia, Evaluation of cutaneous immune response in a controlled human in vivo model of mosquito bites

Epithelial-Associated Immune Responses

Chairs

• Luisa Cervantes-Barragan, Emory Univ.
• Theresa Alenghat, Cincinnati Children's Hosp. Med. Ctr.

Speakers

• Dan Corral, NIAID, NIH, Maternal immune regulation of lactogenesis
• Ellen Merrick Schill, Washington Univ. in St. Louis Sch. of Med., early life antibiotic exposures inhibits postnatal enteric nervous system maturation and alters neonatal neuroimmune interactions
• Emily M. Eshleman, Cincinnati Children's Hosp. Med. Ctr., Microbiota dampen type 2 immunity by epigenetically restricting tuft cell differentiation
• Chuan Wu, NCI, NIH, Lipid sensing by gut CD1d calibrates peripheral serotonin release
• Ankit Malik, Univ. of Chicago, Compartmentalized antigen presentation and inflammasome activation between epithelial cells and macrophages orchestrates gut immunity
• Deepika Sharma, Univ. of Chicago, Neuronal cells co-ordinate myeloid-epithelial cell interaction to regulate intestinal inflammation
• Bibiana E. Barrios, Washington Univ. in St. Louis Sch. of Med., MHCII expression by intestinal goblet cells in immune homeostasis
• Natasha B. Golovchenko, Rutgers New Jersey Med. Sch., γδ intraepithelial lymphocyte number and motility precede the onset of Crohn's disease-like ileitis.

Immune Responses to Microbial, Parasitic, and Fungal Infections

Chairs

• Tiffany Weinkopff, Univ. of Arkansas Sch. of Med.
• Olanrewaju Morenikeji, Univ. of Pittsburgh

Speakers

• Sumanta Kumar Naik, Washington Univ. in St Louis Sch. of Med., Determining the mechanistic basis for Irgm1 mediated control of Mycobacterium tuberculosis infection
• Subhajit Roy, Univ. of California, Irvine, Host gut-resistome and gut-immune axes are the key to non-cholera Vibrio infection severity in aging and heat stress
• Camila Farias Amorim, Univ. of Pennsylvania, Staphylococcus aureus promotes increase IL-1 mediated immunopathology and delayed healing in cutaneous leishmaniasis
• Miguel Antonio Bernabe Mercado, Univ. of Arkansas for Med. Sci., Transcription factor Bhlhe40 plays a protective role during intravaginal Chlamydia muridarum infection in mice
• Lee Ann Garrett-Sinha, State Univ. of New York at Buffalo, Dendritic epidermal T cells (DETC) are not required for control of skin Staph infections
• Purevdorj B. Olkhanud, NCI, NIH, Bi-directional crosstalk between gut microbiota and NKT cells
• Lucy Fry, Univ. of Arkansas for Med. Sci., Distinct lymphatic remodeling is associated with healing and non-healing murine cutaneous leishmaniasis
• Lila T. Witt, Mayo Clin., γδ T cells contribute to immunopathology during neonatal sepsis in an age-dependent manner

Immune Therapy in Cancer

Chairs

• Michael A. Farrar, Univ. of Minnesota Med. Sch.
• Tyler J. Curier, Dartmouth Col.

Speakers

• Xinyi Tu, Mayo Clin., A new PD-L1 antibody H1A causse PD-L1 degradation and sensitizes cancer cells for cytotoxic therapy
• Ling Li, Erasmus Univ. Med. Ctr., Netherlands, ITK inhibition improves the response to immune checkpoint blockade in solid tumors
• Hrishi Venkatesh, Univ. of Minnesota, B cell leukemia elicits a suppressive Tr1-like CD4 T cell response that can be reversed with anti-PDL1-blockade
• Tina Kwok, Mayo Clin., The effects of αPD-1 and αPD-L1 therapy on macrophage remodeling within the solid tumor microenvironment
• Michael Walsh, Massachusetts Gen. Hosp., IL-21 or synthetic IL-2 treatment drives T cell IFNγ production or expansion, respectively, during adoptive cell therapy of melanoma
• Vivien Ileana Maltez, NIAID, NIH, Hijacking suppression: anti-CD40 converts regulatory T cells Into type I effectors
• Clare Murray, The Univ. of Texas Hlth. Sci. Ctr. at San Antonio, Pharmacologic tumor PDL1 depletion as a novel approach to overcome treatment resistance
• Miho Tanaka, Univ. of California, San Francisco, An immunosuppressive tumor population drives immunotherapy resistance of heterogeneous tumors
• Christina Kratzmeier, Univ. of Maryland Sch. of Med., Unique immunoregulation of lung cancer by CD8+ T cells

Innate Immune Responses and Host Defense

Speakers

• Christine Youn, Johns Hopkins Univ. Sch. of Med., TNF receptors orchestrate differential neutrophil responses critical to immunity against Staphylococcus aureus skin infection
• Kimberly Oliva, Univ. of Georgia, Inflammation-induced development and migration of a novel monocyte-like dendritic cell population that regulates antiviral CD8 T cell immunity
• Skyler V. Hendrix, Washington Univ. in St Louis Sch. of Med., Investigating the role of BHLHE40 in host responses to Mycobacterium tuberculosis infection and myeloid cell development
• Eden Faneuff, Vanderbilt Univ. Med. Ctr., Myeloid PTEN inhibits innate host defense during methicillin-resistant Staphylococcus aureus-induced sepsis
• Helen Eva Adams Rich, Univ. of Michigan, Epithelial TLR9 upregulation by respiratory viruses impairs pulmonary antibacterial immunity
• Roshan Ghimire, Oklahoma State Univ., Differential role of TLR7 signaling in SARS-CoV-2-induced antiviral and inflammatory responses
• Lindsey D. Hughes, Yale Univ. Sch. of Med., Effector response to necroptotic cell death: an ensemble of immune and stromal cells
• Aaron P. Esser-Kahn, Univ. of Chicago, Identifying and targeting a subpopulation of dendritic cells with enhanced activation of adaptive responses—identifying first responders

Innate Sensing and Disease

Chairs

• Justin E. Wilson, Univ. of Arizona Cancer Ctr.
• Zizhen Kang, Univ. of Iowa

Speakers

• Thierry Gauthier, NIDCR, NIH, TGF-β promotes glycolysis through PFKL in activated macrophages and exacerbates sepsis by disrupting blood coagulation
• Karla Yvonne García-Martínez, Cornell Univ., A role for stimulator of interferon genes in toll-like receptor 8 signaling
• Stefanie M. Bader, Walter and Eliza Hall Inst. of Med. Res., Australia, TNF mediates inflammation and cytokine release through Caspase-8 during SARS-CoV-2 infection in vivo
• Alex J. Suptela, Univ. of North Carolina at Charlott, Human microglial responses to DNA damage are mediated by the cytosolic sensor cGAS
• Yuhang Wang, Univ. of Iowa, An animal model for autoinflammation with infantile enterocolitis
• Andrew G. Harrison, Univ. of Connecticut Hlth. Ctr., The glucose transporter GLUT4 tethers RIG-I-like receptors to suppress antiviral immunity
• Justin E. Wilson, Univ. of Arizona, AIM2 promotes epithelial tuft cell development during intestinal type 2 immune responses
• Abigail Morales, Hunter College, DNA-PKcs regulates transcriptional networks in activated macrophages

Metabolic and Gut Microbiota: Effects on Autoimmunity

Chairs

• Rahman Ziaur, Penn State Univ. Col. of Med.
• Reiko Horai, NEI, NIH

Speakers

• Kristen N. Bricker, Penn State Univ. Col. of Med., miR-21 promotes B cell autoreactivity, inflammatory signaling, and metabolism in TLR7-driven systemic autoimmunity
• Niyati Jhaveri, Akoya Biosciences, Inc., Single-cell spatial phenotyping of immune and metabolic landscapes in systemic lupus erythematosus
• Tarun Pant, Med. Col. of Wisconsin, Lnk/Sh2b3 modulates bioenergetic metabolism of activated CD8 T cells and control the development of Type 1 Diabetes
• Angela M. Thornton, NIAID,NIH, Acquired lipodystrophy is mediated by a Treg cpecific deletion of helios
• Vidyanath Chaudhary, Hosp. for Special Surgery, Regulation of plasmacytoid dendritic cells by ER stress-mediated metabolic responses
• Jing Ma, Univ. of Louisville, Intestinal lamina propria stromal cells function as the target of androgens and microbiota metabolites for the prevention of lupus
• Stephanie R. Peterson, Univ. of Iowa, Gut microbiome-derived isoflavone metabolites may ameliorate experimental autoimmune encephalomyelitis (EAE) through estrogen receptor signaling in CD8 T-cells
• Amy Zhang, NEI, NIH, Human gut commensals support development of ocular autoimmunity in retina-specific T cell receptor transgenic mice

Myeloid Cells in Cancer Hosts I

Chairs

• Melanie R. Rutkowski, Univ. of Virginia
• Tracy McGaha, Univ. Hlth. Network

Speakers

• Mitchell Thomas McGinty, Univ. of Virginia, Absence of Toll-like receptor 5 confers survival in mice bearing ovarian tumors treated with anti-PD-L1
• Anthony Michael Cannon, Indiana Univ. Sch. of Med., IL-9 responsive macrophages utilize Arginase 1 to enhance lung tumor growth
• Devanshi A. Nayak, Univ. of Pittsburgh Sch. of Med., Elucidating the role of heat shock protein receptor CD91 on antigen presenting cells during cancer immunosurveillance
• Sara Lamorte, Univ. Hlth. Network, Canada, Medullary sinus macrophages limit cancer therapy efficacy by an efferocytosis-induced IL-33/ST2 axis in the tumor-draining lymph node
• Olivia J. Cheng, Univ. of Utah Sch. of Med., MAIT cell-mediated inhibition of colorectal tumor growth is associated with increase in IL-5 and accumulation of eosinophils in the tumor microenvironment
• Hyun-Jin Kim, Korea Adv. Inst. of Sci. and Technol., South Korea, Monocyte-derived CD169⁺ macrophages advance the antitumor immunity against glioblastoma multiforme

Vaccination and Vaccine-induced Responses against Pathogens at Target Sites

Chairs

• Mangala Rao, Walter Reed Army Inst. of Res.
• Todd Bradley, Univ. of Kansas Med. Ctr.

Speakers

• Dennis Lapuente, Univ. Hosp. Erlangen, Germany, Adenoviral vector vaccines are effective mucosal booster modalities to elevate systemic and establish mucosal immunity against SARS-CoV-2
• Qin Xu, NIAID, NIH, mRNA vaccination induces persistent pharyngeal mucosal B cell responses to SARS-CoV-2 in children
• Wenxia Jiang, Indiana Univ. Sch. of Med., Boosting location of COVID-19 mRNA vaccine regulates the germinal center reaction
• Devdoot Majumdar, Univ. of Vermont, Understanding mechanisms of adjuvancy in muscle by mRNA/lipid nanoparticles
• Eric S. Geanes, Children's Mercy Kansas City, Blocking respiratory syncytial virus infection utilizing decoy ICAM-1 receptor proteins
• Chunhong Dong, Georgia State Univ., Particulate characteristics of engineered nanoparticle vaccines modulate vaccine immunogenicity in an intranasal route
• Allison N. Bucsan, NIAID, NIH, Visualizing the early immune response to Mycobacterium tuberculosis infection in macaques immunized with intravenous BCG

Adaptive Responses at the Mucosa

Chairs

• Brian Kelsall, NIAID, NIH
• Kathryn A. Knoop, Mayo Clin.

Speakers

• Byunghyun Kang, NIAID, NIH, Segmented filamentous bacteria (SFB) drives enhanced T cell-dependent IgA and IgG2b responses in Peyer's patches
• Claudia A. Rivera, NIAID, NIH, Endogenous retroviruses act as a tonic signal for Treg induction and oral tolerance development
• Alexandria Wells, NIAID, NIH, Adaptive immunity to ancient retroelements controls the skin tissue threshold of activation
• Carla R Nowosad, New York Univ. Grossman Sch. of Med., Tunable dynamics of B cell selection in gut germinal centers
• Fiona Ann Raso, Univ. of Massactusetts Chan Med. Sch., Microanatomical lipid niche controls intestinal memory B cell migration and effector function
• Jung-Shan Hsu, Univ. of Alabama at Birmingham, Synergy between anti-commensal antibodies and IL-10 in gut homeostasis and disease
• Talia Raitt Cheifetz, Mayo Clin., Premature Treg induction in early life results in FoxP3 instability post-weaning
• Kazuki Nagashima, Stanford Univ., Mapping the T cell repertoire to a complex defined gut bacterial community

Approaches to Improve Vaccination and Immunotherapy Against Pathogens

Chairs

• Catarina E. Hioe, Icahn Sch. of Med. at Mount Sinai
• Luc Teyton, Scripps Res. Inst.

Speakers

• Eric Wang, MIT, Nanoparticle geometry, immune memory, and antigen presentation determine the cross-reactive antibody response against sarbecoviruses
• Jonah S. Merriam, NIAID, NIH, Genetic immunization with self-assembling SARS-CoV-2 Spike-HBsAg nanoparticles
• Noemia Lima, NIAID, NIH, Prime-boost immunization against COVID-19 with adenovirus-vectored or mRNA vaccines induces different phenotypes of memory B cells
• Sarah Sanchez, Feinberg Sch. of Med., Northwestern Univ., 4-1BB costimulation following mRNA vaccination improves CD8 T cell responses
• Vamsee Mallajosyula, Stanford Univ. Sch. of Med., Calibrating T cell help by antigen cross-linking as a universal vaccine platform against rapidly evolving pathogenic viruses
• Aaron P. Esser-Kahn, Univ. of Chicago, Modulating innate immune responses for improved vaccine tolerability and durability
• Jonothan A. Rosario-Colon, Louisiana State Univ. Hlth. Sciences Ctr., Universal Candida cell-surface-specific monoclonal antibodies protect mice against multidrug-resistant Candida auris bloodstream infections
• Kenna K. Nagy, Scripps Res. Inst., Therapeutic anti-glycan antibodies against antibiotic resistant Staphylococcus aureus

Cytokine & Chemokine Control of Cellular Immunity

Chairs

• Katherine Gallagher, Univ. of Michigan Med. Sch.
• Magali Noval Rivas, Cedars Sinai Med. Ctr.

Speakers

• Stephanie Ann Mills, Medical Univ. of South Carolina, IL-12 alters T-cell metabolism to augment anti-tumor immunotherapy
• Elizabeth M. Hill, Univ. of Maryland Sch. of Med., A novel heterodimer composed of IL-12p40 and CD5L promotes a unique cytokine profile from T cells
• Payam Fathi, Vanderbilt Univ., Central nervous system IL-17R expression influences weight gain by altering food-intake and fat-mass accumulation
• Howard H Zhang, NIAID/NIH, Studies in humans and mice reveal a critical role for CCR2 in trafficking of pDCs during infection with SARS-CoV-2
• Thacyana Teixeira de Carvalho, Cedars-Sinai Med. Ctr., IL-33 promotes cardiovascular lesions development in a mouse model of Kawasaki Disease
• Holly Marie Scott Algood, Vanderbilt Univ. Med. Ctr., IL-17 Receptor A protects against Helicobacter pylori-induced gastric cancer
• Sonya Wolf, Univ. of Michigan, Diabetic wound keratinocytes induce macrophage JMJD3-mediated Nlrp3 expression via IL1R signaling
• Megan Elisabeth Borregard, Univ. of Chicago, It takes a village: STATs control IE-CTL pathogenesis in Celiac Disease

Epigenetic, Transcriptional, and Post-transciptional Regulation of Autoimmunity

Chairs

• Christpoher Scharer, Emory Univ. Sch. of Med.
• Laurence Morel, The Univ. of Texas Hlth. Sci. Ctr. at San Antonio

Speakers

• Jean A. Lee, Univ. of Chicago, Androgen Receptor regulates Ptpn22
• Phillip P. Domeier, Benaroya Res. Inst., Foxp3 exon 2 regulates keratinocyte-specific IgE and basophil extracellular traps in cutaneous autoimmune photosensitivity
• Charlotte Nicole Hill, Boston Children's Hosp., Harvard Med. Sch., IL2 signaling and Foxp1 expression maintain Treg identity in the absence of Foxp3
• Yuk Pheel Park, Univ Texas Hlth. Sci. Ctr. in San Antonio, Molecular mechanisms of PBX1 regulation of CD4⁺ T cell inflammatory phenotypes
• Nada Salem Alakhras, Indiana Univ. Sch. of Med., An IL-23/STAT4 axis regulates classical dendritic cell expansion and function in CNS autoimmunity
• James R. Rose, Emory Univ. Sch. of Med., Early peripheral B cells in inactive SLE are transcriptionally and epigenetically primed for T-dependent activation
• Rachel Elizabeth Sutton, Emory Univ. Sch. of Med., Impacts of the A20 protein polymorphism, rs2230926, in human B cells
• Daniel L. Seiler, Univ. of Lübeck, Germany, The impact of the often neglected second C5a receptor, C5aR2, on neutrophil-driven autoimmune diseases

Regulation of Immune Responses

Chairs

• Connie Krawczyk, Van Andel Inst.
• Steven Josefowicz, Weill Cornell Med.

Speakers

• Caitlin C. Zebley, St Jude Children's Res. Hosp., Conserved epigenetic hallmarks of T-cell age
• Michael Duane Powell, Emory Univ. Sch. of Med., Tissue-specific heterogeneity of human T follicular helper cells marked by unique transcriptomes and regulatory architecture
• Michael J. Bale, Weill Cornell Med., IKKa-mediated phosphorylation of Histone H3.3 localizes at loci associated with differentiation in CD4⁺ T cells
• Jin Gyu G. Cheong, Weill Cornell Med., Epigenetic memory of COVID-19 in innate immune cells and their progen­itors­­
• Chao Chen, Emory Univ. Sch. of Med., Mitochondrial metabolic flexibility is critical for CD8 T cell anti-tumor immunity
• Erika M. Palmieri, NCI, NIH, Pyruvate Dehydrogenase operates as an intramolecular nitroxyl generator during macrophage metabolic reprogramming
• Ameeta Kelekar, Univ. of Minnesota, Novel function for gluconeogenic enzyme, FBP1, in T cell activation and expansion
• Wesley H. Godfrey, Johns Hopkins Univ. Sch. of Med., Inhibition of distinct glycolytic enzymes produces differential effects on CD4 T cell function

Technological Innovations in Immunology: Immune Responses and Tissue Microenvironments

Chairs

• Jeffrey Hubbell, Univ. of Chicago
• Sterling B. Ortega, Univ. of North Texas Hlth. Sci. Ctr.

Speakers

• Arnon Arazi, The Feinstein Inst. for Med. Res., Northwell Hlth., A novel method for studying intercellular networks: quantifying cellular cooperativity and inferring the extracellular signals driving it
• Claire E. Gustafson, Allen Inst. for Immunology, Tri-modal single cell (TEA-seq) profiling reveals a novel, epigenetically distinct T cell subset in children and global molecular reprogramming across age
• Lisa R. Volpatti, Univ. of Chicago, Engineered cytokines target atherosclerotic plaques and locally suppress inflammation
• Huy Dinh, Univ. of Wisconsin, Madison, Comparative single-cell transcriptome analysis informs early innate immune response in severe human burns
• Bruce A. Adams, 10x Genomics, An integrated reagent and multimodal analysis workflow to enrich and characterize peptide-specific CD8⁺T cells
• Niyati Jhaveri, Akoya Biosci., Multiomic spatial phenotyping of the tumor immune microenvironment at single cell resolution
• Paul Zdinak, Univ. of Pittsburgh Sch. of Med., CD4⁺ T cell epitope identification de novo
• Tim Sindelar, Canopy Biosci., Spatial immunoprofiling of tissue sections with ChipCytometry™

Transplant Immunology: from Alloreactivity to Immunoregulation

Chairs

• Jonathan Bromberg, Univ. of Maryland, Baltimore
• Maria-Luisa Alegre, Univ. of Chicago

Speakers

• Julia Miranda R. Bazzano, Emory Univ., Gm2a as a novel regulator of CD8⁺ T cell threshold of activation in transplantation
• Erik H. Koritzinsky, Cleveland Clin. Lerner Res. Inst., Allograft TLR9 is required for endogenous donor-reactive memory CD8 T cell activation to mediate CTLA-4Ig resistant rejection of high-risk cardiac allografts
• Michael Nicosia, Cleveland Clin. Fndn., Water channel Aquaporin 4 is required for T cell activation
• Jennifer Brianne Allocco, Univ. of Chicago, Variegated levels of alloreactive T cell dysfunction in transplantation tolerance determine graft vulnerability to infection-triggered rejection
• Giorgio Raimondi, Johns Hopkins Sch. of Med., Solid organ and vascularized composite allotransplantation have distinct requirements for localized delivery of enhanced costimulation blockade to control rejection
• Young S. Lee, Univ. of Maryland Sch. of Med., Purine metabolic pathway regulates regulatory T cell stability and function
• Ping Zhang, Fred Hutchinson Cancer Res. Ctr., Type-1 regulatory T cells are critical for curative immunotherapy outcomes
• Jemma H. Larson, Univ. of Minnesota, Human CAR19 CD8⁺ iTreg exceed CAR19 CD8 CTLs both in suppressing GVHD lethality and eliminating CD19⁺ Nalm-6 lymphoma cells in vivo

Tumor Cellular Therapy

Chairs

• Gregoire Altan-Bonnet, NCI, NIH
• Tessa Bergsbaken, Rutgers New Jersey Med. Sch.

Speakers

• Adam Kenet, NCI, NIH, The 1000 mouse experiment: quantifying the variability of tumor response to CAR T cell therapy
• Emily Simon Rav, Univ. of Texas MD Anderson Cancer Ctr., Targeting CD70 using CAR NK cells to enhance NK cells cytolytic effect against osteosarcoma
• Kole R. DeGolier, Univ. of Colorado Anschutz Med. Campus, Antigen experience history directs distinct functional states of CD8⁺ CAR T cells during the anti-leukemia response
• Jennifer Cimons, Univ. of Colorado Anschutz Med. Campus, T-bet overexpression modulates CAR T cell effector functions
• Asmaa Mohamed, Geisel Sch. of Med., Dartmouth Col., CD4 depletion enhances the efficacy of Super2 IL-33 armored CAR T cell against solid tumors and leads memory formation of both endogenous and CAR T cells
• Menglin Cheng, Rutgers Sch. of Grad. Studies, Investigating tissue-resident memory T cell differentiation of CAR T cells reveals an unexpected role for CD69
• Jing Wang, Chinese Univ. of Hong Kong, Investigating the role of HDAC8 in CD4⁺ T cells

CD8⁺ T Cell-mediated Immunity to Viral Infections

Chairs

• Emily Hemann, Ohio State Univ. Col. of Med.
• Susan Kaech, Salk Inst. for Biol. Studies

Speakers

• Madison R. Mix, Univ. of Iowa, Acute and chronic viral infection generate brain-resident memory T cells with distinct phenotypic, functional, spatial, and metabolic profiles
• Jennifer Berger, Univ. of Colorado Anschutz Med. Campus, Bystander CD8⁺ T cells are important antiviral effectors in the brain
• Katheryn M. Wininger, Mayo Clin. Grad. Sch. of BioMed. Sci., Dissecting the role of H-2D^b class I molecule in the development of brain atrophy during Theiler's murine encephalomyelitis virus (TMEV) infection
• Anna-Maria Globig, Salk Inst. for Biol. Studies, Adrenergic receptors regulate T cell differentiation in viral infection and cancer
• Lisbeth Disla, Ohio State Univ., Interferon-lambda modulates dendritic cell IL-10 production and CD8 T cell immunity during influenza A virus infection
• Xinran Wang, Univ. of Alabama at Birmingham, Regulatory maturation of lung cDC1 is required for resolution of Influenza infection
• E. Lake Potter, NIAID, NIH, Serial intravascular staining reveals altered T cell trafficking in aged and SIV⁺ rhesus macaques

Findings from Amphibians, Fish, and Chickens to Mammals

Chairs

• Crystal L. Loving, ARS, USDA
• Ro Miller, Univ. of New Mexico

Speakers

• Jordan M. Sampson, Univ. of New Mexico, Evolution of the structure and organization of the mammalian immunoglobulin loci
• Luke S. Hebert, Univ. of Texas, Austin, Characterization of the B cell receptor repertoire and discovery of new immunoglobulin genes in the domestic ferret
• Aryana Razmara, Univ. of California, Davis, Single cell and genomic profiling of PBMC-expanded NK cells in first-in-dog clinical trial of allogeneic adoptive NK cell therapy for dogs with cancer
• Channakeshava Sokke Umeshappa, Dalhousie Univ., Canada, Computational prediction of highly conserved CD8⁺ and CD4⁺ T cell epitopes in bluetongue virus: A promising data for developing broad-spectrum bluetongue vaccine
• Judy L. Cannon, Univ. of New Mexico, Benefits of being big: how a T cell response can occur as rapidly in a human as a mouse

Immunometabolism and Anti-tumor Immunity

Chairs

• Jeffrey C. Rathmell, Vanderbilt Univ.
• Kyle K. Payne, Rutgers Cancer Inst. of New Jersey

Speakers

• Paola Cappello, Univ. of Turin, Italy, Iron-overload affects anti-tumor immune response in pancreatic cancer
• Joanina K. Gicobi, Mayo Clin., Resilient CD8⁺ T cells maintain a high cytotoxic capacity by balancing ROS and energy needs via ME1 upregulation
• Paramita Chakraborty, Medical Univ. of South Carolina, Sphingosine 1-phosphate / Acetyl CoA Carboxylase1 axis regulates the differentiation and function of tumor-associated myeloid-derived suppressor cells
• Hai Huang, Feinstein Inst. for Med. Res., Pre-operative exercise therapy suppresses colorectal liver metastases by triggering anti-tumor trained immunity of Kupffer cells
• Chuan-Teng Liu, China Med. Univ. Hosp., Taiwan, Immunometabolic modulation by targeting UCP2 and IL-17A boost anti-tumor immunity against pancreatic cancer
• Emilie L. Fisher, Vanderbilt Univ. Med. Ctr., Improving anti-tumor CD8⁺ T cell function through manipulating glutamine metabolism
• Meng-Han Wu, Univ. of Colorado Anschutz Med. Campus, Modulating T cell metabolism to improve CAR-T cell therapy success

Non-immune Therapy in Cancer

Chairs

• Arya Biragyn, NIA, NIH
• Rana Herro, Cincinnati Children’s Hosp. Med. Ctr.

Speakers

• Jiandong Huang, The Univ. of Hong Kong, Attenuated Salmonella blocks cancer metastasis by activating NK cells in an IFN-γ-dependent manner
• Kaiting Yang, Univ. of Chicago, Zinc-c-di-AMP nanoparticles target and suppress tumors via endothelial STING activation and tumor associated macrophage reinvigoration
• Jugal Kishore Das, Texas A&M Univ. Hlth. Sci. Ctr., Engineered live attenuated bacteria producing 5-hydroxyindole remodels heterogeneous tumor microenvironment and promotes antitumor immunity
• Soha M. Kazmi, NIAID, NIH, Global inhibition of Ly-49/MHC-I interactions by anti-MHC-I augments innate and adaptive immunity against cancer metastasis
• Lei Wang, Univ. of Florida Col. of Med., Proteolysis-targeting chimera against NR4A1 for cancer immunotherapy
• Sharmila Nair, Univ. of Louisville, Advancing Immunovirotherapy with Zika virus to treat high-grade brain tumors
• Raziye Piranlioglu, Brigham and Women's Hosp. and Harvard Med. Sch., Assessment of the impact of oncolytic virotherapy on the immunopeptidome profile of tumor by utilizing GEMM derived immunocompetent GBM models
• Sevasti Karaliota, Frederick Natl. Lab. for Cancer Res., Synergy of heterodimeric IL-15 immunotherapy and a fatty acid metabolism modulator enhances intratumoral lymphocyte metabolism and eradicates EO771 murine breast tumors

Regulation of Cytotoxic Lymphocytes During Infection

Chairs

• Christopher Jondle, Western Michigan Univ. Homer Stryker Sch. of Med.
• Laura Snell, Indiana Univ. Sch. of Med.

Speakers

• William D. Green, Univ. of North Carolina at Chapel Hill, Pinpointing molecular regulators of CD8 T cell differentiation through multimodal single-cell profiling
• Andrea C. Pichler, NIAID, NIH, PI3Kδ: a key driver of effector differentiation under conditions of T cell exhaustion
• Devin M. Jones, Ohio State Univ. Col. of Med., Aiolos restrains acquisition of a cytotoxic program by CD4⁺ T cells
• Namita Rout, Tulane Univ. Sch. of Med., Impaired IL-17 and cytotolytic responses to influenza vaccine antigens in aging nonhuman primates
• Kunal Dhume, Univ. of Central Florida, Direct and indirect type I interferon signaling regulates eomes-driven Th1-responses against influenza virus
• Cassandra R. Winter, Univ. of Washington Sch. of Med., The role of bystander activation among CD8αα T cells in controlling Mycobacterium tuberculosis infection
• Mohamed Khalil, Medical Col. of Wisconsin, Single cell transcriptomes from HCMV⁺ donors reveal a unique NKG2C^High subset that represents true memory NK cells
• Shaon Sengupta, Perelman Sch. of Med., Univ. of Pennsylvania, Role of NK cells in circadian regulation of lung inflammation

Regulators of Lymphocyte Fate and Activation

Chair

• Jennifer Cannons, NIAID, NIH

Speakers

• Peter Pioli, Univ. of Saskatchewan, Canada, Thymus antibody-secreting cells possess an interferon-responsive gene signature and are comprised of a CD154(CD40L) dependent plasmablast population
• Doureradjou Peroumal, Univ. of Pittsburgh Sch. of Med., Kidney disease impairs B cells response against infection via inhibiting germinal center formation and antibody titers
• Roy Neal Mulpur, Emory Univ. Sch. of Med., CRISPR/Cas9 screen of B cell differentiation pathways
• Marie Pineault, Université Laval, Canada, The mutation PTPN6^Ala455Thr causing pulmonary emphysema affects B cell populations and causes spontaneous pulmonary tertiary lymphoid tissue formation
• Michela Locci, Perelman Sch. of Medicine, Univ. of Pennsylvania, IL-12 drives the differentiation of human T follicular regulatory cells
• Dominic P. Golec, NIAID, NIH, PI3Kδ shapes Th2 lineage restriction through coordination of IL-2 signaling, Foxo1 inactivation and epigenetic remodeling
• Danielle Alexandria Chisolm, NIAMS, NIH, PAXBP1 serves as a novel regulator of t helper specification by restraining the type 1 program
• Jessica A. Gaevert, St. Jude Childrens Res. Hosp., Characterization, functional validation, and analysis of the cross-reactive T cell repertoire in the context of heterosubtypic influenza A virus infection

Cytokines and Vaccines for the Treatment of Cancer

Chairs

• Jenny Jiang, Univ. of Pennsylvania
• Michelle Krogsgaard, New York Univ. Sch. of Med.

Speakers

• Kyle J. Kaeo, Johns Hopkins Univ., Engineering antibody fusion proteins for targeted intracellular therapeutic delivery
• Max Mu Wang, Northwestern Univ., Design and optimization of a novel proteomimetic polymer nanoplatform for the co-delivery of antigens with adjuvants
• Haiyan Liu, Natl. Univ. of Singapore, RNA-based personalized cancer vaccine for AML immunotherapy
• Aliyah Brianne Silver, Johns Hopkins Bloomberg Sch. of Public Hlth., Design and characterization of a tumor-retained interleukin-2 cytokine/antibody fusion protein for cancer immunotherapy
• Yuanzhi Bian, Virginia Tech, Cytometric analysis authenticates adjuvanticity of interferon-γ and suggests potential synergy with toll-like receptor agonists
• Kou Hioki, Erasmus Univ. Med. Ctr., Netherlands, A combination of TLR9 and STING agonists induces potent neopeptide-specific T cell immunity and improves ICB efficacy in tumor models
• Jianmei Wu Leavenworth, Univ. of Alabama at Birmingham, Reshaping the anti-tumor CD4 T-cell repertoire contributes to oncolytic virus therapeutic efficacy in malignant glioma
• Rachel P. Wallace, Univ. of Chicago, Synthetically mannosylated antigens impair the antigen-specific humoral immune response and prolong the therapeutic efficacy of immunogenic protein drugs

Emerging Approaches in Oncology and Autoimmunity

Chairs

• Daniela Cipolletta, Seismic Therapeut.
• Jane Grogan, Graphite Bio

Speakers

• Stephanie J. Grebinoski, Seismic Therapeut., IMPACTing autoimmunity through dual targeting of antigen presenting cells and T cells via inhibitory receptor agonism
• Hsi-Ju Wei, AbbVie, Targeting dendritic cell inhibitory receptors to down regulate immune response in inflammatory disease
• Linya Wang, Twist Biosci., Functional DKK1 antibodies demonstrate antagonistic and tumor suppression activities
• Katherine Christine Upchurch-Ange, Boehringer Ingelheim Phamaceut., Characterization of a novel therapeutic antibody targeting peptide/HLA-E
• Andrew W. Woodham, Emulate, Chimeric antigen receptor-T cell efficacy can be evaluated on an Organ-Chip model system
• Efthymia Papalexi, Parse Biosci., Using split-pool combinatorial barcoding to simultaneously characterize the transcriptome and TCR diversity of 1 million T cells
• Anushka Dikshit, Advanced Cell Diagnostics, Multiplexed RNA-protein co-detection to explore tumor-immune landscape using a novel automated RNAscope™ assay
• Daniel L. Adams, CreatvBIO, PD-L1 expression on circulating antigen presenting macrophages in blood predicts PFS & OS in an array of metastatic cancer types treated with PD-L1/PD-1 immunotherapies

Express Yourself: Molecular Events in Antigen Presentation

Chairs

• Marlene Bouvier, Univ. of Chicago
• Scheherazade Sadegh-Nasseri, Johns Hopkins Univ.
• Pamela A. Wearsch, Case Western Reserve Univ.

Speakers

• Michael J. Hogan, Children's Hosp. of Philadelphia, Cryptic MHC-E epitope from influenza elicits a potent cytolytic T cell response
• Jesus Contreras Rodriguez, Johns Hopkins Unic., Decrypting pMHCI diversity through noncanonical translation initiation
• Malini Raghavan, Univ. of Michigan Med. Sch., Endo-lysosomal assembly variations among human leukocyte antigen class I (HLA-I) allotypes
• Marlene Bouvier, Univ. of Illinois Chicago, Visualization and characterization of the elusive MHC I intermediate states by x-ray crystallography and in silico studies
• Adrian Martin-Esteban, John Hopkins Med. Inst., The ER aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities
• Kannan Natarajan, NIAID, NIH, Mechanistic aspects of tapasin-mediated antigen presentation revealed by structure of a tapasin/MHC-I complex
• Viva Jeanne Rase, Univ. of Utah, Human versus mouse Beta 2 microglobulin alters TCR antigen recognition kinetics with mouse MHCI
• Amanpreet Kaur, Univ. of Michigan Med. Sch., Mass spectrometric profiling of HLA-B44 peptidomes provides evidence for Tapasin-mediated Tryptophan editing

Vascular and Pulmonary Immunology

Chairs

• Katharina Maisel, Univ. of Maryland
• Rana Herro, Cincinnati Children’s Hosp. Med. Ctr.

Speakers

• Jana Lovell, Johns Hopkins Univ. Sch. of Med., Serum proteomic analysis of peripartum cardiomyopathy reveals a unique disease with distinctive dysregulation of inflammatory and cholesterol metabolism pathways
• Maria Serena Longhi, Beth Israel Deaconess Med. Ctr., Harvard Med. Sch., Selective inhibition of estrogen receptor alpha restores regulatory T-cell function in autoimmune hepatitis
• Kabeerdoss Jayakanthan, Post Grad. Inst. of Med. Educ. & Res., India, Combined analysis of DNA methylation and single-cell RNA sequencing in CD8 T-cells reveals increased interferon and TGF-Beta signalling in patients with Takayasu arteritis
• Shahad Iqneibi, Augusta Univ., Single cell transcriptomic changes of CD8 T cells in male and female patients with coronary artery disease and diabetes
• Aditi Murthy, Perelman Sch. of Med., Univ. of Pennsylvania, Regulatory T cells in the fibrotic milieu: ontological characterization from initiation through remodeling in a murine model of spontaneous pulmonary fibrosis
• Tania Estefania Velez, Univ. of Virginia, Expanded T regulatory cells fail to control germinal center responses in the lung lymph nodes of pulmonary fibrosis patients
• Keisuke Fukutomi, NIDDK, NIH, Pathogenesis of flares in liver inflammation in hepatitis B virus-infected women during and after pregnancy

Being Schooled: New Strategies for Immunology Education

Chairs

• Heather A. Bruns, Univ. of Alabama at Birmingham
• Raffaella Ghittoni, Univ. of Southern California

Speakers

• Rachel Gerstein, Univ. of Massachusetts Chan Med. Sch., DRIVE: Diversity, Representation, and Inclusion for Value in Education—interprofessional faculty development for a bias-free curriculum at UMass Chan Medical School
• Heather A. Bruns, Univ. of Alabama at Birmingham, Assessment of factors that impact the quality and penetrance of immunology into the curriculum at the secondary education level in Alabama
• Jastaranpreet Singh, Univ. of Toronto, Canada, Bridging statistics and life sciences education for immunologists: Exploring significantly impactful teaching strategies and collaborations
• Michelle Snyder, Towson Univ., Results from a CURE course project reveal novel insights into the structure of bacterial Toll/interleukin-1 receptor (TIR) domain proteins
• Crystal C. Walline, Univ. of North Carolina at Pembroke, Smart textbooks and LMS-integrated digital tools incentivize student engagement and facilitate learning in an undergraduate immunology course
• Raffaella Ghittoni, Univ. of Southern California, Meta-lecture: the educational experience of reversed roles
• Pascale Alard, Univ. of Louisville, Jedi mindset: discussing wffective learning strategies with students

Food Allergy, Atopic Skin, and Mast Cells

Chairs

• Adrian Piliponsky, Seattle Children's Res. Inst.
• Rebecca Martin, Virginia Commonwealth Univ. Sch. of Med.

Speakers

• Lauren A. Hesser, Univ. of Chicago, A single species bacterial therapy reduces type 2 immune responses in the gut to prevent food allergy
• Julia Johnston, NIAID, NIH, Identification of the novel human serine protease σ-tryptase: a gene fusion product at TPSB2
• Irina Miralda Molina, Seattle Children's Res. Inst., Dedicator of cytokinesis 8 (DOCK8) is a negative regulator of skin mast cell function
• Tamara Haque, NIAID, NIH, Cell-intrinsic effects of TGF-b signaling in mast cell effector function that modulate allergic inflammation
• Heather L. Caslin, Vanderbilt Univ., Weight cycling may induce lipid handling in mast cells
• Rahul Sharma, NHLBI, NIH, BLOC1S1: an unexpected regulator of Th2 cell-driven inflammatory responses
• Timothy C. Borbet, New York Univ. Sch. of Med., Loss of microRNA-29 in B cells leads to atopic skin phenotype in mice
• Matthew Zellner, Virginia Commonwealth Univ., B1-like B cells derived from the bone marrow and not fetal-derived B1 B cells are responsible for the protective IgE induced in helminth infection

Immune Responses in the Respiratory Tract

Chairs

• Jacob Kohlmeier, Emory Univ. Sch. of Med.
• Yee Ling Wu, Loyola Univ.

Speakers

• Marco Künzli, Univ. of Minnesota, Iteratively stimulated T cells as tools to understand mechanisms of nonlymphoid recirculation
• Kimberly Oliva, Univ. of Georgia, Regulation of respiratory CD8⁺ T cell immunity by suppressive monocyte-like dendritic cells
• Jorna Sojati, Univ. of Pittsburgh Sch. of Med., The upper respiratory tract exhibits reduced interferon Response that contributes to limited CD8⁺ T Cell Recruitment and delayed clearance of human metapneumovirus
• Sarah Michalets, Emory Univ. Sch. of Med., Upper respiratory tract resident memory CD8 T cells limit viral transmission and provide durable protection
• Alexander J. Nelson, Loyola Univ., Allergen inhalation transforms the lungs into a permissive environment for local IgE responses
• Bruna de Gois Macedo, Mayo Clin., Lung pathogenic, P2RX7-dependent CD4⁺ T cell immune responses to influenza are exacerbated by co-exposure with lung allergens
• Chi Tai, Natl. Taiwan Univ. Col. of Med., Taiwan, Enteric helminth infection confers protection against lethal respiratory influenza virus infection
• Alexander Dale Ethridge, Univ. of Michigan, Respiratory syncytial virus promotes allergic predisposition via gastrointestinal microbiome alteration

Halt! Regulation of Lymphocyte Signaling

Chairs

• Andrew Snow, Uniformed Serv. Univ. of the Hlth. Sci.
• Patricia Gearhart, NIA, NIH

Speakers

• Stormy Elizabeth Ruiz, NIA, NIH, Establishing novel and unique technology to uncover how Activation-Induced Deaminase specifically targets immunoglobulin regions
• Tiffany K. Ybarra, Univ. of Iowa, Mechanisms of TRAF3 regulation of TLR signaling in B lymphocytes
• Deborah Yablonski, Technion, Israel, Gads is differentially required for the thymic development of conventional and innate-like T cells
• Kumarkrishna Raychaudhuri, NCI, NIH, Kinetic regulation of TCR activation as a potential mechanism for CD28 co-stimulation
• Justin Boxuan Zhang, Monash Univ., Australia, Re-evaluating the role of coreceptor: LCK association in T cell receptor signalling
• Bradly M. Bauman, Uniformed Services Univ. of the Hlth. Sci., Dominant interfering CARD11 variants disrupt JNK signaling in T cells and impaired CARD11-JNK signaling increases expression of GATA3
• Thomas H. Mann, Salk Inst. for Bio. Studies, Discovery of a molecular clock that controls CD8⁺ T cell function and exhaustion
• Akshaya Balasubramanian, Geisel Sch. of Med., Dartmouth Col., An old dog with "new" tricks: the MDR1 transporter in T cell-mediated immunity

Molecular Regulation of Innate Immunity

Chairs

• Lu Huang, Univ. of Virginia
• Sarah Ewald, Univ. of Virginia

Speakers

• Clinton J. Bradfield, NIAID, NIH, Biphasic JNK signaling reveals distinct MAP3K complexes licensing inflammasome formation and pyroptosis
• Michael Reginald Pitter, Univ. of Michigan, PAD4 controls the anti-tumor response by fine-tuning IFNγ signaling in macrophages
• Alvina Deka, Natl. Inst. of Immunology, India, A noncanonical NF-kB - β-catenin signaling axis in dendritic cells instructs gut inflammation
• Katherine Camille Barnett, Univ. of North Carolina at Chapel Hill, Bi-directional epithelial-immune communication amplifies inflammasome activation and IL-6 release during SARS-CoV-2 infection
• Zachary T. Peters, Dartmouth Col., Immune checkpoint VISTA regulates DNA sensing and repair pathways that contribute to type I interferon (IFN-I) production in the skin
• Savita Devi, Cedar Sinai Med. Ctr., CARD-only proteins (COPs) inhibit uric acid crystal-induced inflammasome activation and ameliorate gout
• Hemant Joshi, Washington Univ. in St Louis Sch. of Med., Mechanical signaling regulates NLRP3 activation in macrophages

Myeloid Cells in Cancer Hosts II

Chairs

• Stanley Huang, Case Western Reserve Univ.
• Weiping Zou, Univ. of Michigan Med. Sch.

Speakers

• Jiajia Zhou, Univ. of Michigan Med. Sch., STAT3 restrains dendritic cell function and tumor immunity
• Arya Biragyn, Natl. Inst. on Aging, Cancer promotes immune escape via transdifferentiating B cells into macrophage-like cells
• Michelle A. Tran, Icahn Sch. of Med. at Mount Sinai, Unraveling myeloid cell-mediated mechanisms of resistance to immune checkpoint blockade in bladder cancer
• Ziyan Zoe Xu, Salk Inst. for Biol. Studies, Scavenger receptor CD36 regulates inflammatory and type-I interferon responses in tumor-associated macrophages
• Thejaswini Giridharan, Roswell Park Comprehensive Cancer Ctr., Neutrophils in the tumor microenvironment (TME) induce T cell non-responsiveness characterized by a shift from proliferation and activation to lipid transport pathways
• Melissa Romain Bonner, Case Western Reserve Univ., PIEZO1 deletion in CD11b⁺ cells suppresses rhabdomyosarcoma tumor rejection and generates a tumor-permissive immune landscape

T Cells in Cancer: From Memory to Exhaustion

Chairs

• Hazem Ghoneim, Ohio State Univ. Wexner Med. Ctr.
• Zihai Li , Ohio State Univ. Comprehensive Cancer Ctr.

Speakers

• Delaney E. Ramirez, Geisel Sch. of Med., Dartmouth Col., Temporal requirements for TGF-β and IL-7 in generating resident memory T cell responses to melanoma
• Sierra A. Kleist, Geisel Sch. of Med., Dartmouth Col., Investigating the source of viral-specific memory T cells in glioblastoma
• Anwesha Kar, Indian Inst. of Chemical Bio., India, CD38-cADPR axis mediated chronic Ca²⁺ signaling promotes the differentiation of TCF1^lo terminal exhausted CD8⁺ T cells in tumor
• Tong Xiao, James Comprehensive Cancer Ctr., Ohio State Univ., Novel mechanisms of androgen receptor-centered transcriptional regulatory network in regulating CD8⁺ T cell exhaustion and sex bias in cancer
• Xin Lan, St. Jude Children's Res. Hosp., Exhausted CD8 T cell progenitors are sustained with TCR engagement during anti-tumor responses
• Hannah Dada, NCI, NIH, Effect of mechanical cues on T cell killing of cancer cells
• Amir Yousif, Ohio State Univ. Col. of Med., Targeting epigenetic crosstalk that restrains the responses of exhausted T cells to immune checkpoint blockade therapy
• Emilia Rae Dellacecca, Mayo Clin., DUSP2 functions as a negative regulator of cytotoxic T cell responses in cancer immunotherapy

Cellular Mechanisms of Immune Response Regulation: B Cell Responses and Immunity in the Skin

Chairs

• Matthew Kudek, Med. Col. of Wisconsin
• Nancy Monson, Univ. of Texas, Southwestern

Speakers

• Rachel George, NIAID, NIH, B cell responses to membrane-presented antigens require the function of the mechanosensitive calcium channel Piezo1
• Jaeyong Jung, Rutgers—The State Univ. of New Jersey, Effects of IL-9 on TRAF3-deficient B cell activation
• Lance K. Blevins, Michigan State Univ., Single cell transcriptomics identify AHR and CD9 as markers of CD14⁺ atypical B cells
• Renan de Carvalho, Rockefeller Univ., Clonal replacement sustains long-lived germinal centers primed by respiratory viruses
• Aurélie Bouteau, Thomas Jefferson Univ., Steady-state Langerhans cells induce Tfh and B cell responses through a type I interferon and IL-6 independent mechanism
• Otgonzaya Ayush, NIAMS, NIH, Injury-induced hair growth response is promoted by tissue macrophages via insulin-like growth factor 1
• Wenwu Zhang, Indiana Univ. Sch. of Med., The therapeutic role of fibronectin in the re-epithelialization response following wounding in a human skin/mouse xenografting model
• Wenwu Zhang, Indiana Univ. Sch. of Med., Diminished γδ T Cells during allergic skin inflammation is mediated by IL-4 signaling in keratinocytes

Controlling Immune Responses to Microbial, Parasitic, and Fungal Infections:  Inflammation and Vaccination

Chairs

• Bolaji N. Thomas, Rochester Inst. of Tech.
• Richard Lee Reinhardt, Nat. Jewish Hlth.

Speakers

• Jessica R. Taddeo, Lewis Katz Sch. of Med., Temple Univ., Investigating the lipid-immune signaling axis in modulating the inflammatory response to Salmonella enterica serovar Typhimurium infections
• Albersy Armina-Rodriguez, Univ. of Puerto Rico Med. Sci. Campus, Fasciola hepatica Fh15 promote survival in a mouse septic shock model and downregulates inflammatory cytokines
• Som G. Nanjappa, Univ. of Illinois, Urbana-Champaign, Sialophorin is an essential host element for vaccine immunity against pulmonary fungal infections
• Bridget Alexander, Univ. of Colorado Anschutz Med. Campus, Neonatal helminth infection and chronic type 2 inflammation promotes immune suppression through FcγRIIb
• Andrew W. Simonson, Univ. of Pittsburgh Sch. of Med., CD8⁺ lymphocytes contribute to immunologic bottlenecks in Mycobacterium tuberculosis infection
• Blanda Di Luccia, Stanford Univ. Sch. of Med., Gut regulatory T cells mediate immunological tolerance in Salmonella-infected super-spreader hosts
• Om Prakash Singh, Banaras Hindu Univ., India, CD4⁺ T cells show a cytolytic phenotype functions in human visceral leishmaniasis
• Joselyn Natasha Allen, Walter Reed Army Inst. of Res., Plasmodium falciparum liver stage antigens as mRNA vaccine induce divergent B cell and CD4 T cell responses in mice

Immune Cell Drivers of Human Disease

Chairs

• Elizabeth Leadbetter, Univ. of Texas Hlth. Sci. Ctr. at San Antonio
• Sarah Henrickson, Univ. of Pennsylvania

Speakers

• Jessica Maya, Cornell Univ., Investigating T cell populations for immune cell exhaustion in myalgic encephalomyelitis/chronic fatigue syndrome
• Raphael Reyes, UT Hlth. San Antonio, Plasticity of atypical B cell composition and function in response to malaria
• Antoine M. Guerin, Garvan Inst. of Med. Res., Australia, Strong adaptive immunity in humans with inherited CD4 deficiency
• Deborah L. Cross, Univ. of Washington Sch. of Med., MR1-restricted T cell clonotypes are associated with resistance to Mycobacterium tuberculosis infection
• David S Iu, Cornell Univ., Single cell immune atlas of myalgic encephalomyelitis/chronic fatigue syndrome identifies substantial transcriptional dysregulation
• Jose S. Campos Duran, Perelman Sch. of Med., Univ. of Pennsylvania, Amplified STAT3 signaling alters expression of CD39 in STAT3 gain-of-function (STAT3 GOF) and in healthy donor CD8⁺ T cells
• Kevin D. Mangum, Univ. of Michigan, Ann Arbor, The histone methyltransferase Whsc1 regulates TGFβ-driven macrophage to myofibroblast transition

Regulation of B Cells and Role of Antibodies in Autoimmunity

Chairs

• Emily Moser, Univ. of Florida Col. of Med.
• Jason D. Weinstein, Rutgers New Jersey Med. Sch.

Speakers

• Shili Li, Univ, of Texas, San Antonio Hlth., B cell Tet2 promotes maturation of the antibody response through active DNA demethylation and OGT-mediated histone glycosylation of Aicda and Prdm1 loci
• Chien-Hsin Huang, Genomics Res. Ctr., Academia Sinica, Taiwan, Dissecting the functional role of SENP2 in B cells and systemic lupus erythematosus
• Marie Dominique Ah Kioon, Hosp. for Special Surgery, CXCL4, a chemokine upregulated in systemic sclerosis patients, abrogates TLR9 signaling and central tolerance in B cells
• Kathryn Sullivan, Univ. of Alabama at Birmingham, Sch. of Med., 17β-estradiol and B-cell intrinsic type I interferon amplify toll-like receptor 7 signaling loop in B cells of female lupus prone BXD2 mice
• Danni Zhu , Harvard Med. Sch., Follicular B cell derived CD21^lo B cells are immediate precursors to autoreactive extrafollicular antibody secreting cells 5
• Gina Marie Sanchez, Rutgers Bio. and Hlth. Sci., Impaired expansion and selection of geminal center B cells in lupus drives autoantibody-producing cells
• S. Janna Bashar, Univ. of Wisconsin, Madison, Macrophage extracellular traps require peptidylarginine deiminase 2 and 4 and are a source of citrullinated antigens bound by rheumatoid arthritis autoantibodies

Wasting Thyme: Thymus Function in Health and Disease

Chairs

• Jarrod A. Dudakov, Fred Hutchinson Cancer Res. Ctr.
• Mercedes Rincon, Univ. of Colorado

Speakers

• Lauren Ilyse Richie Ehrlich, Univ. of Texas, Austin, CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tolerance
• Chloe Houques, IGMM, Thymic innate lymphoid cells promote thymocyte differentiation of transplanted hematopoietic progenitors in immunodeficient mice
• Felipe Pereira, Univ. of Colorado Anschutz Med. Campus, Inactivation of GSK3β by Ser³⁸⁹ phosphorylation prevents thymocyte necroptosis and impacts Tcrβ and Tcrα repertoire diversity
• Yong Fan, Allegheny Singer Res. Inst., Tissue engineering human thymus from iPSCs to support human T cell development
• Menglin Jiang, St. Jude Children's Res. Hosp., Genetic tracing of thymic T cell differentiation
• Sarah A. Wedemeyer, Unversity of Texas, San Antonio Hlth., Role of paracrine mTOR signaling in regulating thymus size and function
• D. Tyler Boone, Geisel Sch. of Med., Dartmouth Col., NDRG3 is a novel regulator of T and B cell development with phosphorylation-specific activity and phenotypes
• Shil Patel, NCI, NIH, Harnessing spatial transcriptomics to study fate decisions and lineage specification in T cell development

Big Data and Tumor Immunology

Chairs

• Dorina Avram, H. Lee Moffitt Cancer Ctr. and Res. Inst.
• Jose R. Conejo-Garcia, Duke Univ.

Speakers

• In Kang, Korea Advanced Institute of Sci. and Technol., The landscape of glioma-infiltrated immune cells after immune checkpoint blockade treatment
• Sabina Kaczanowska, NCI, NIH, Deep myeloid cell profiling provides new insights into modulators of CAR T cell expansion in patients with pediatric solid tumors
• Timothy P. McMullen, Univ. of California, Irvine, Insights into the regulation of brain metastasis by natural killer cells using single-cell RNA sequencing and imaging mass cytometry
• Emanuel Salazar Cavazos, NCI, NIH, Analyzing the immunological variability in T cell/tumor interactions to identify a subpopulation of CD8⁺ T cells (Spark T cells) that drives succesful cancer immunotherapy
• Sepideh Dolatshahi, Univ. of Virginia, Sch. of Med., Systems approaches to characterize the local heterogeneities in NK cell antitumor immunity in MHC I-disparate human non-small cell lung cancer
• ByeongHoon Kang, Korea Advanced Institute of Sci. and Technol., Single cell RNA sequencing reveals heterogenous immune landscape of tumor infiltrated immune cell population against glioblastoma

Infectious Etiology of Diseases

Chairs

• Gianna Hammer, Univ. of Utah
• Ning Jenny Jiang, Univ. of Pennsylvania

Speakers

• Jennifer Leigh Cannons, NIAID, NIH, PI3Kdelta coordinates transcriptional, epigenetic and metabolic changes to promote effector CD8 T cells differentiation
• Camilo Daniel Cabrera-Garcia, Universidad de Concepcion, Chile, Patients who develop insulin resistance 4-months post-COVID-19 exhibited higher NETosis and miR-21-5p expression than COVID-19 patients without metabolic alterations
• Charitha Madiraju, Hackensack Meridian Sch. of Med., Immune regulatory markers in clinical cases of COVID-19
• Norihide Jo, Kyoto Univ., Japan, Delayed CD4⁺ T-cell response in older adults is associated with reduced immunogenicity and reactogenicity after COVID-19 mRNA vaccination
• James Oscar Moore-Stanley, Univ. of Manchester, United Kingdom, Paradoxically Increased Inflammation in Immunosuppressed Individuals with COVID-19
• Rajesh Parmar, Univ. of California, Los Angeles, Integrated transcriptomic analysis reveals T and B cell immune signatures influencing resolving outcome in MRSA bacteremia
• Lucie Rodriguez, Karolinska Institutet, Sweden, Immune system perturbations in patients with severe long COVID
• Michael J. Malone, Univ. of Pennsylvania, The immunodominant SARS-COV-2 CD8⁺ T cell repertoire is capable of resisting antigenic drift

Metabolic and Migratory Pathways of Leukocytes in Inflammation

Chairs

• Dequina Nicholas, Univ. of California, Irvine
• Luis Franco, NIH

Speakers

• Wu Yuanyuan, Uconn Health, Distinct roles of kindlin-3 and talin-1 in neutrophil beta2 integrin clustering
• Ariel M. Bohner, NIAMS, NIH, In vivo cell tracking reveals the pattern of neutrophil tissue distribution at baseline and in response to glucocorticoid treatment
• Honghong Sun, Perelman Sch. of Med., Univ. of Pennsylvania, TIPE proteins control directional migration of human T cells via GPCR and lipid second messenger signaling
• Naveena Ujagar, Univ. of California, Irvine, Th17 cells of type 2 diabetic patients present an aberrant fatty acid metabolic pathway
• Jessica Huang, Univ. of Washington, Dendritic cells regulate innate cell trafficking and lymph node organization during inflammation
• Farhat Parween, NIAID, NIH, Extravasation of pathogenic human type 17 Th cells requires both endothelial cell-bound and non-cell bound chemokines
• Shamik Majumdar, NIAID, NIH, Ackr1-deficient mice are protected from lethal SARS-CoV-2 challenge
• Marianne Kanellias, Emulate, Inflammatory bowel disease (IBD)-specific immune cell recruitment and response can be modulated with anti-TNF-α therapies in the human colon intestine-chip

The Tumor Microenvironment: Novel Immune Checkpoints and Mechanisms of Immune Suppression

Chairs

• Defne Bayik, Univ. of Miami
• Jun Wang, New York Univ.

Speakers

• Juyeun Lee, Cleveland Clin. Fndn., Loss of testosterone leads to impaired T cell function via glucocorticoids in mouse glioblastoma models
• Lucas F. Loffredo, Columbia Univ. Irving Med. Ctr., Exploring the effects of tissue structural cell and tumor cell heparan sulfate on immune system trafficking, activation, and intercommunication via amphiregulin
• Ameet A. Chimote, Univ. of Cincinnati Col. of Med., A novel ion channel-mediated mechanism facilitates the inhibitory effect of exosomes on anti-tumor immune responses
• Ru Wen, Stanford Univ. Sch. of Med., Siglec-7/9 are novel immune checkpoints for prostate cancer
• Gabriel J. Rodriguez-Garcia, Vanderbilt Univ., Tumor cell secretome induces the expression of the immune checkpoint NKG2A on CD8⁺ T cells
• Qiao Lu, New York Univ. Grossman Sch. of Med., A membrane-associated inhibitory axis of MHC-I presentation for cancer immune evasion
• Venkata Krishna Kanth Makani, Univ. of Pittsburgh, Discovery of human papilloma virus and patient-specific neoantigens targeted by CD8⁺ T cells in HNSCC

Barrier Inflammation and Repair

Chairs

• Sangwon Kim, Thomas Jefferson Univ.
• Sherrie Divito, Brigham and Women’s Hosp. and Harvard Med. Sch.

Speakers

• Anastasia de Poulpiquet du Halgouet, NIDCR, NIH, Role of MR1-driven signals and amphiregulin on the recruitment and repair function of skin MAIT cells
• Xiaopeng Fu, Brigham and Women’s Hosp. and Harvard Med. Sch., Use of dirty mice to study skin resident memory T cells in cancer treatments and graft-versus-host-disease
• Himanshi Tanwar, Univ. of Maryland Sch. of Dentistry, The interconnection between periodontitis and inflammatory bowel disease
• Xiangsheng Huang, niv. of Texas Hlth. Sci. Ctr., Houston, Bile acid conditioned Dendritic cells through FXR and specialize T cell function in the ileum
• Yi Dong, Johns Hopkins Univ. Sch. of Me, Investigating the interaction of inflammation-associated fibroblasts (IAFs) with colon epithelial cells in inflammatory bowel disease (IBD
• Sangwon V. Kim, Thomas Jefferson Univ., Dietary L-tryptophan determines the number of colonic regulatory T-cells and susceptibility to colitis via GPR15
• Shunichi Tayama, Tohoku Univ., Japan, Reactive persulfide controls intestinal inflammation by suppressing CD4⁺ T cell proliferation
• Nuria Tubau-Juni, NIMML Institute, Host metabolic reprogramming ameliorates disease severity and colitis during Clostridioides difficile infection

Location, Location, Location: Cancer, Skin, Neurology, and Immunology

Chairs

• Aharon Freud, Ohio State Univ. Wexner Med. Ctr.
• John B. Sunwoo, Stanford Univ.

Speakers

• Jadie Yoonjoo Moon, Univ. of Michigan, IL-17A-mediated JMJD3 regulation of integrin alpha 3 gene expression alters migration of diabetic keratinocytes and impairs wound repair
• Tze-Yen Lin, Natl. Taiwan Univ. , Salt-induced maladaptive innate immune memory impedes stroke recovery
• Shahab Chizari, Univ. of Pennsylvania, High-throughput multidimensional characterization of CD8 T cells in MOG antibody-associated disease
• Jiaqing Hao, Univ. of Iowa, Keratinocyte FABP5-VCP complex mediates recruitment of neutrophils in psoriasis
• Jack Prazich, Univ. of Pennsylvania, High-dimensional analysis of the T cell response in multiple myeloma and the potential efficacy of harnessing tumor-reactive CD8 T cells
• Jugmohit Toor, Henry Ford Health, Dysregulation of circulating MAIT cell subsets in patients with hidradenitis suppurativa
• Christine Joh, Seoul Natl. Univ. Col. of Med., Spatial transcriptomic profiling reveals the pathophysiology of early stage hidradenitis suppurativa
• Soyoung Jeong, Seoul Natl. Univ. Col. of Med., High-dimensional profiling of circulating dendritic cells and monocytes in atopic dermatitis patients by mass cytometry

Mechanisms of Viral Sensing and Innate Immune Responses

Chairs

• Jeffrey Tomalka, Emory Univ.
• Susan Kovats, Oklahoma Med. Res. Fndn.

Speakers

• Philippe M. Rascle, Duke Univ. Sch. of Med., Single-cell cloning of NK cells from rhesus macaques: a new methodology for in-depth analysis of MHC-E-dependent adaptive functions
• Esther Lee, Duke Univ. Sch. of Med., Elucidating the role played by the NKG2 family of receptors in natural killer cell responses to JC polyomavirus
• Jeffrey Alan Tomalka, Emory Univ. Sch. of Med., STINGing CD4+ T cells to induce refractoriness to HIV infection
• Andrew J. Suh, Georgetown Univ., Gp120 envelope glycoproteins of HIV-1 Group M Subtype A and Subtype B differentially affect gene expression in human vascular endothelial cells
• Abigael Parrish Williams, Oklahoma Med. Res. Fndn., Sex differences in ILC2 function in influenza result from imprinted donor sex intrinsic factors independent of host sex in competitive female-male bone marrow chimeras
• Ivan Kosik, NIAID, NIH, The complement protein C1q modulates the activities of anti-influenza HA-stem and anti-SARS-Cov2-nonRBD antibodies and alters viral evolution
• Natasha M. Kafai, Washington Univ. Sch. of Med. in St. Louis, The entry receptor LDLRAD3 is critical for Venezuelan equine encephalitis virus pathogenesis and neuroinvasion in mice

Molecular Mechanisms of Cytokine Function

Chairs

• Ken J. Oestreich, Ohio State Univ. Col. of Med.
• Warren Leonard, NHLBI, NIH

Speakers

• Suyasha Roy, NHLBI, NIH, Blimp-1 is a negative regulator of IL-2 signaling in T cells
• Hiroyuki Nagashima, NIAMS, NIH, Distinct 3D remodeling of Il4-Il13-Il5 loci mediates differential type 2 responses in innate versus adaptive lymphocytes
• Melissa Leonard, Ohio State Univ. Col. of Med., The Ikaros zinc finger transcription factor Aiolos as a novel regulator of T cell migration
• Cheuk Lam Cheung, Indiana Univ. Sch. of Med., Identification of a novel interleukin-9 receptor complex in non-hematopoietic cells
• Anagha Yogam , NCI, NIH, Bottoms up!: inferring relevant immune phenotypes from bulk cytokine kinetics via semi-supervised machine learning
• Ang Cui , Broad Inst. of MIT and Harvard, Dictionary of immune responses to 86 cytokines in vivo at single-cell resolution
• Satya Singh, NIAID, NIH, Human CCR6⁺ Th cells show both an extended stable gradient of Th17 activity and imprinted plasticity
• Rachael Laura Philips, NIAMS, NIH, STAT1 gain of function mutation impairs immune response to viral infections

Technological Innovations in Immunology: Identifying, Modulating, and Modeling Immune Responses

Chairs

• Lalit Beura, Brown Univ.
• Yuri Sykulev, Thomas Jefferson Univ.

Speakers

• Kaitlyn Emily Bambino, Univ. of North Texas Hlth. Sci. Ctr., Cerebral organoids: A novel tool for neuroimmunologists
• Leo Chan, Nexcelom from PerkinElmer, Comparison of CAR-T cell-mediated cytotoxicity assays with suspension tumor cells using high-throughput plate-based image cytometry method
• Nadia Anikeeva, Thomas Jefferson Univ., A novel approach for identification of highly potent pathogen specific human CD8 T cells from peripheral blood
• Max R. Ulibarri, Brown Univ., Establishment of a vaginal organoid system to study local resident memory T cell differentiation
• Adriana Tomic, Boston Univ., SIMON, a powerful AI software accelerating discovery of human immune memory responses to viruses
• Oliver Kask, Arizona State Univ., HLA-PopSeq: high throughput, multiplexed six-locus Human Leukocyte Antigen typing for population-scale T cell immune profiling using rapid long-read nanopore sequencing
• Alex George, Columbia Univ. Irving Med. Ctr., A lymph node slice culture model to characterize T cell activation dynamics and anti-viral responses in human tissue
• Si-Sim Kang, Johns Hopkins Univ. Sch. of Med., Using nanoparticles as artificial antigen presenting cells to mobilize CD4 T cells for immunotherapy

Diet/Microbiome and Metabolites in Health

Chairs

• Sangeeta Khare, NCTR, FDA
• Veena Taneja, Mayo Clin. Rochester

Speakers

• Verena M. Link, NIAID, NIH, Highly controlled nutritional interventions uncover defined immune and microbiome responses in human
• Rafael Aniu Peres-David, Univ. of Hawaii, Manoa, Gut microbiome and metabolites relate diabetes risk among Native Hawaiians and Pacific Islanders
• Priyanka Saminathan, La Jolla Inst. for Immunology, Bio-active lipids protect against immune-related adverse events due to immune checkpoint blockade therapy
• Marmar R. Moussa, Univ. of Connecticut Sch. of Med., Role of walnut-derived urolithins in reducing colonic inflammation in a patient cohort elucidated by an integrated omics analysis
• Taisuke Kondo, NCI, NIH, Harnessing arginine metabolism overcomes hyperthermia-induced metabolic dysfunction of CAR T-cells
• Adebowale Bamidele , Mayo Clin. Rochester, IL21 Receptor-Deficient Regulatory T Cells promote resolution of intestinal inflammation by resisting metabolic disturbance
• Sardar T.A.K. Sindhu, Dasman Diabetes inst., Kuwait, Endoplasmic reticulum stress promotes the expression of TNF-α in monocytic cells by mechanisms involving ROS/CHOP/HIF-1α and MAPK/NF-κB pathways

Host–Microbiota Crosstalk

Chairs

• Neil Surana, Duke Univ.
• Shipra Vaishnava, Brown Univ.

Speakers

• Girak Kim, NCI, NIH, Mucus sialylation determines intestinal host-commensal homeostasis
• Edward Ionescu, Univ. of Chicago, Gut microbiome-derived isodeoxycholic acid promotes mucosal immune non-responsiveness
• Chin Yee Tan, Duke Univ. Sch. of Med., A commensal-derived exopolysaccharide regulates ILC3-mediated diseases
• Robert T. Patry, Univ. of Chicago, The differential influence of commensal and pathogenic flagella on intestinal barrier function
• Deanna M Pepin, Univ. of British Columbia, A vanishing family of commensal bacteria and its impact on host health and disease
• Charlie Chung, Cold Spring Harbor Lab., Microbial regulation of anti-tumor immunity in colorectal cancer
• Teruyuki Sano, Univ. of Illinois, Chicago, Commensal-specific CD4 T cells can promote inflammation in the central nervous system via molecular mimicry
• Victor I. Band, NIAID, NIH, Sulfides in the gut mediate protection against gastrointestinal infection via alterations to local immunity and the microbiome

Innate Immune Signal Transduction Pathways during Infection

Chairs

• Sunny Shin, Perelman Sch. of Med., Univ. of Pennsylvania
• Jonathan Kagan, Boston Children's Hosp. and Harvard Med. Sch.

Speakers

• Neha Dubey, Washington Univ. Sch. of Med. in St Louis , Mycobacterium tuberculosis exploits FIP200 regulated cell-death pathways to promote replication
• Alexander Rapp, Geisel Sch. of Med., Dartmouth Col., Uncovering alterations in the murine interferon response due to dsRNA mycovirus during Aspergillus fumigatus infection
• Lynn Soong, Univ. of Texas Med. Br. at Galveston, Syk-dependent responses and Innate cytosolic defenses in Orientia tsutsugamushi-infected macrophages
• Reena Agrawal-Rajput, Indian Inst. of Adv. Res., Chlamydia trachomatis infection renders M2 generation to mediated immunosuppression
• Alex A. Compton, NCI, NIH, The extracellular tail of IFITM3 promotes SARS-CoV-2 entry into cells and is diversifying in primates
• Cheyanne Foster, Case Western Reserve Univ., Double DAMPs—NLRP3 priming of murine bone marrow derived mast cells with IL-33 leads to robust IL-1β secretion in a Gasdermin-D independent manner
• Thu R. Nguyen, Case Western Reserve Univ., Murine eosinophils release IL-1β via a non-lytic mechanism dependent on gasdermin D (GSDMD) expression but independent of GSDMD proteolytic processing
• George R. Dubyak, Case Western Reserve Univ., Lyososome membrane permeabilization induces plasma membrane macropores to activate K⁺-efflux-dependent NLRP3 inflammasomes in murine dendritic cells

Innate Lymphocytes in Cancer

Chairs

• Jose R. Conejo-Garcia, Duke University
• Kyle K. Payne, Rutgers Cancer Inst. of New Jersey

Speakers

• Pakhi Birla, Johns Hopkins Univ. Sch. of Med., Immune checkpoint blockade unleashes Mucosal Associated Invariant T (MAIT) cells in tumor microenvironment of NSCLC patients
• Natalia Lehman, Med. Univ. of Lublin, Poland, γδ T cells are significantly suppressed in glioma patients but retain their cytotoxic potential
• Subbarao Bondada, Univ. of Kentucky, Redox extracellular vesicles induce neurotoxic cytokine production from innate immune cells
• Valentina Cazzetta, Univ. of Milan, Targeting γδ T cells for the immunotherapy of endometrial cancer
• Emilie Boucher , Université Grenoble Alpes, Inulin enriched diet reinforces cancer immunosurveillance via γδ T cell activation
• Abdulaziz O. Alshwimi, Univ. of Cincinnati, Regulation of NK cell chemotaxis by KCa3.1 channels
• Priscila Silva, Goethe-University Frankfurt, Targeting lL-38 triggers γδ T cell-dependent anti-tumor immunity
• Valeriya Kuznetsova, Univ. of Alabama at Birmingham, Inflammation perturbs NK cell phenotype and function in chronic myeloid leukemia (CML)

Generously supported by JDRF

Innovations in the Manipulation of T Cells for Treating Autoimmune Diseases

Chairs

• Amit Awasthi, Translational Hlth. Sci. and Technol. Inst.
• Silva Markovic-Plese, Thomas Jefferson Univ.

Speakers

• Patrick Ho, Univ. of California, San Francisco, Elucidating inflammation-induced cell fate decisions in primary human Tregs
• Woogil Song, Korea Adv. Inst. of Sci. and Technol., Characterization and neutralization of pathologic memory CD4⁺ T cells in spondyloarthritis synovial fluid
• Manal Ali Elzoheiry, Thomas Jefferson Univ., Microparticle-delivered stimulator of interferon genes (STING) agonist suppresses experimental autoimmune encephalomyelitis (EAE) via expansion of FoxP3⁺ CD4⁺ Tregs
• James E. DiLisio, Univ. of Colorado Anschutz Sch. of Med., Suppression of IGRP-specific CD8 T cells following induction of tolerance to a Hybrid Insulin Peptide CD4 neoepitope
• Upasna Madan, Translational Hlth. Sci. and Technol. Institute, India, Artemotil mediates protection in experimental colitis through the induction of Type 1 regulatory T cells
• Andrew J. Leber, NIMML Inst., Activation of PHACTR2 with oral NIM-1001 treatment enhances regulatory CD4⁺ T cell function and provides protection from systemic lupus erythematosus
• Christine Bender, Benaroya Res. Inst., Ex vivo activation and fold-expansion of human regulatory T cells negatively correlates with preservation of beta cell function in adolescents with type 1 diabetes
• Kevin G. Senior, Univ. of Florida Col. of Med., Liver cells transduced with AAV.MOG increase the frequency of MOG-specific T regulatory cells capable of reducing EAE by adoptive transfer

Into the Grove: Antigen Processing and Presentation

Chairs

• David H. Margulies, NIAID, NIH
• Paul Roche, NCI, NIH

Speakers

• Robin A. Welsh, Johns Hopkins Univ. Sch. of Med., HLA-DO promotes Treg differentiation by altering antigen presentation
• Kevin Hsu, NCI, NIH, Understanding NKT cells through sulfatide analogues
• Yating Li, Univ. of Texas MD Anderson Cancer Ctr., Investigating the role of Quaking in dendritic cells
• Rebecca Danner, Med. Col. of Wisconsin, Expanded presentation of Lyme autoantigens and identification of a novel immunogenic CD4⁺ T cell epitope from Borrelia burgdorferi MCP4 in murine Lyme arthritis
• Mark Andrew Maynes, Mayo Clin. Grad. Sch. of BioMed. Sci., Cell-specific MHC class I deletion on CD11c⁺ APCs abrogates CD8 T Cell infiltration into the brain
• Shaodong Dai, Univ. of Colorado Anschutz Med. Campus, Heterogeneous specificities of nickel presentation to nickel specific CD4 T cells
• Juliana Schneider Powell, Univ. of Pittsburgh Sch. of Med., Extracellular vesicles deliver feto-placental paternal antigens to maternal secondary lymphoid tissues for T cell recognition
• Nianbin Song, Johns Hopkins Univ. Sch. of Med., Loss of HLA-DO function impairs the development of memory CD4 T cells

Novel Therapeutic Targets for Controlling Immune Responses and Dampening Inflammation

Chairs

• Brad Hoffman, Univ. of Florida
• Steven Kerfoot, Univ. of Western Ontario

Speakers

• Joshua A. Taylor, NIA NIH, Unmasking arterial-resident autoreactive B cells involved in atherosclerosis and peripheral Artery disease progression
• Maroua Ferhat, OncoOne Res. & Dev. GmbH, Austria, ON104, a novel antibody targeting oxidized macrophage migration inhibitory factor (oxMIF) shows efficacy in preclinical models of chronic inflammation
• Amber Simone Griffith, Washington Univ. Sch. of Med. in St. Louis, Selective targeting of auto reactive B cells using bispecific molecules
• Shaikh Nisar Ali, Long Island Univ., 1,25-dihydroxy vitamin D enhances the differentiation of intestinal stem cells Ex Vivo and In Vivo
• Steven Kerfoot, Univ. of Western Ontario, Systemic administration of anti-CD20 indirectly reduces B cells in the inflamed meninges in a chronic model of central nervous system autoimmunity
• Lauren Stewart Stafford, Univ. of Florida, Novel bio-signature for the topical administration of a suppressor of cytokine signaling-1 mimetic to the equine eye: implications in treatment of recurrent uveitis (RU)
• Gaurav Kumar, Oklahoma Med. Res. Fndn., BAFF and APRIL signaling through BCMA regulates microglial cells in the central nervous system.
• Insha Zahoor, Henry Ford Health, Pro-resolution lipid mediator maresin-1 reduces inflammation, promotes neuroprotection, and prevents disease progression in multiple sclerosis model of autoimmunity

Regulatory T Cell and Macrophage Function in Health and Disease

Chairs

• Bonnie N. Dittel, Versiti Blood Res. Inst.
• Richard Robinson, Ohio State Univ.

Speakers

• Xuan Xie, NIAID, NIH, Eos is a critical transcription factor for T regulatory cell (Treg) function
• Mohammad Nizam Mansoori, NIAID, NIH, CD4⁺Foxp3⁺ Tregs suppress antigen-specific CD8⁺ T cells in vivo by generating an alternative immune synapse resulting in defective T cell activation
• Chaoran Li, Emory Univ. Sch. of Med., Obesity-induced dysregulation of a unique subset of Tregs promotes skin inflammation
• Daniel Seong-Joo Shin, Boston Childrens Hosp., Lung injury induces preferential expansion of Foxp3⁺ regulatory T cells over conventional T cells in self-antigen specific CD4⁺ T cell repertoire
• Romaniya Zayats, Univ. of Manitoba, Canada, Regulatory T cells aid Leishmania major immune evasion by suppressing effector responses against the parasite in an antigen-specific manner
• Tej Ptatap Singh, Univ. of Pennsylvania Sch. of Vet. Med., Regulatory T cells limit opportunistic colonization of Staphylococcus aureus to promote lesion resolution in cutaneous leishmaniasis
• June Guha , NIH, NF kappa B regulator Bcl3 controls development and function of classical dendritic cells required for resistance to Toxoplasma gondii
• Ahmed Rakib, Univ. of Tennessee Hlth. Sci. Ctr., Ablation of Siglec-E enhances adipose tissue inflammation through CXCR3 activation and induces monocytic myeloid-derived suppressor cells

Vaccination against Pathogens at Different Stages of Life and Disease

Chairs

• Bronwyn Gunn, Paul G. Allen Sch. of Global Hlth., Washington State Univ.
• David Weiner, Univ. of Pennsylvania

Speakers

• Alper Cevirgel, Dutch Natl. Inst. for Public Hlth. and the Environment, Netherlands, Baseline immunotypes reveal weak and strong antibody responders to influenza vaccination
• Jacob S. Fisher, Mayo Clin., Aging is associated with accumulated T follicular helper cells with decreased metabolic function
• Sathya Baarathi Shanthi Ravichandran, Jackson Lab. for Genomic Med., Pre-vaccination CD56^dim CD16⁺ NK cell abundance and T_h1/T_h17 ratio predict responsiveness to conjugated pneumococcal vaccine in older adults
• Gina Cusimano, Drexel Univ. Col. of Med., Adenosine deaminase augments SARS-CoV-2 specific cellular and humoral responses in aged mouse models of immunization and challenge
• Elizabeth A. Thompson, Johns Hopkins Univ. Sch. of Med., Heterologous versus homologous boosting regimens elicit qualitatively distinct, BA.5cross reactive T cells in transplant recipients
• Jesse M. Hall, Ohio State Univ. Col. of Med., Characterizing the cellular and humoral immune responses to Tdap during pregnancy compared to non-pregnant controls
• Cody Lauritsen, Paul G. Allen Sch. of Global Hlth., Washington State Univ., Passive antibody transfer from pregnant women to their fetus are maximized after SARS-CoV-2 vaccination irrespective of prior infection
• Caitlin Williams, Weill Cornell Med., SARS-CoV-2 vaccine-elicited antibody responses in breastmilk

Lymphocyte Fate, Maintenance, and Activation

Chairs

• Barbara Kee, Univ. of Chicago
• Mary Philip, Vanderbilt Univ. Med. Ctr.

Speakers

• Yi Ding, NCI, NIH, Two developmental pathways generate functionally distinct populations of natural killer cells
• Roxroy C. Morgan, Univ. of Chicago, Ets1 represses a T-bet dependent migration program and stabilizes the iNKT1 adhesome
• Sandip Ashok Sonar, Univ. Arizona, The age-related changes in lymph node stromal cells underlie defects in peripheral T cell maintenance and immune function decline in old mice
• Daniel Thomas McManus, Emory Univ., Early generation and anatomical commitment of stem-like CD8 T cells
• Natalie Favret, Vanderbilt Univ. Med. Ctr., TCR signaling dynamically regulates TCF1 expression and effector differentiation
• Taylor Heim, New York Univ. Sch. of Med., Resident memory T cells in the lymph node balance localized and systemic protection
• Leena Abdullah, Geisel Sch. of Med., Dartmouth Col., Dynamic single cell lineage recording of endogenous viral specific CD8 T cells reveals multiple potential cell fate pathways
• Alicia Virginia Aguilar, Case Western Reserve Univ. Sch. of Med., Decreased memory persistence in Piezo1 deficient T cells ameliorates disease progression in autoimmune mouse models

Cellular Responses to Microbial, Parasitic, and Fungal Infection

Chair

• Lee Ann Garrett-Sinha, SUNY Buffalo

Speakers

• Fei Chen, Rutgers New Jersey Med. Sch., Neutrophils show distinct patterns of activation in the context of infection with different pathogens
• Elizabeth M. Hammond, Univ. of California, Davis, Ineffective polarization characterizes CD4 T cell responses to persistent Borrelia burgdorferi infection
• Komi Gbedande, Rutgers New Jersey Med. Sch., IL-21 from IFN-g⁺IL-21⁺ hybrid T cells promotes germinal center B cell proliferation
• Steven Tan, Walter Reed Army Inst. of Res., Plasmodium falciparum mRNA liver stage antigens induce antibody and liver CD8 TRM and CD8 T_E cell responses in mice
• Erin Fowler, Ohio State Univ. Col. of Med., Hypoxia promotes cytolytic activity of CD8 T cells and pathogenesis in cutaneous leishmaniasis
• Nicole Maloney Belle, Univ. of Pennsylvania Hlth. System, Trefoil factor 3 via Lingo2 restrains type-1 responses during GI nematode infection
• Raj Priya, Indiana Univ. Sch. of Med., Borrelia burgdorferi c-di-AMP induces type I IFN response in macrophage through the activation of STING signaling pathway
• Jian-Da Lin, Natl. Taiwan Univ., Single-cell multi-omic analysis reveals serum amyloid A3 restrains alternative activations in macrophages derived from different origins

Pathogenesis to SARS-CoV-2 Infection

Chairs

• Pablo Penaloza-MacMaster, Northwestern Univ. Feinberg Sch. of Med.
• Robin Stephens, Rutgers New Jersey Med. Sch.

Speakers

• Solomon Taye Sima, Rutgers Univ. New Jersey Med. Sch., Immunoregulatory roles of TGF-β and IL-4 during mouse-adapted SARS-CoV-2 infection
• Shailendra Kumar Verma, La Jolla Inst. for Immunology, SARS-CoV-2 Delta requires human ACE2 but not human TMPRSS2 to infect mice and elicits greater lung injury and adaptive immune response than Omicron in human ACE2 knock-in mice
• Vadim I. Pivniouk, Univ. of Arizona, IL-13 protects epithelial cells from SARS-CoV-2 infection by inhibiting early ACE2-mediated events
• Emiko Urano, Natl. Inst. of Biomed. Innovation, Hlth. and Nutrition, Japan, Understanding of SARS-CoV-2 pathogenicity in COVID-19 cynomolgus macaque model and consideration of its reinfection
• Paoline Laurent, Hosp. for Special Surgery, Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19
• Fernanda Ana-Sosa-Batiz, La Jolla Inst. for Immunology, A new mouse model expressing human ACE2, TMPRSS2, and FCGRT for evaluating human antibody responses to SARS-CoV-2
• Lisa K. Ryan, Univ. of Louisville, SARS-CoV2 decreases human beta-defensin-1 and FoxI1 in the oral cavity without affecting CFTR

Generously supported by JDRF

T Cell Responses in Autotimmune Disease

Chairs

• Amy Lovett-Racke, Ohio State Univ. Med. Ctr.
• Brian Evavold, Univ. of Utah

Speakers

• Zemin Zhou, Univ. of Utah, DM functions differently in thymic antigen presentation cell subsets in development of autoreactive CD4⁺ T cells
• John P. Driver, Univ. of Missouri, Columbia, Deletion of Vβ3⁺ CD4⁺ T-cells by endogenous mouse mammary tumor virus 3 prevents type 1 diabetes induction by autoreactive CD8⁺ T-cells
• Sanya Arshad, Univ. of Pittsburgh, Identification of T cell autoantigens in a mouse model of lupus nephritis
• Christina N. Rau, Ohio State Univ. Wexner Med. Ctr., miRNAs targeting TGFβ-signaling disrupt Treg development and function in CNS autoimmunity
• Samuel J. Connell, Univ. of Iowa, CD4 T cells from mice with alopecia areata express an effector like phenotype and can transfer disease
• Peter A. Morawski, Benaroya Res. Inst., Cutaneous T cells promote distinct outcomes in human skin structural cells associated with inflammatory disease
• Sydney B. Crotts, Mayo Clin. Grad. Sch. of BioMed. Sci., The role of ST8Sia6 in braking inflammation in inflammatory bowel disease
• Ivy L. Debreceni, Univ. of Iowa, IL-27 promotes pathogenic Tfh-like CD4 effectors and exhausted-like CD8 T cells in a mouse model of Sjögren's

Developing Your Bloody Immune System

Chairs

• Christina Camell, Univ. of Minnesota
• Robert Welner, Univ. of Alabama at Birmingham

Speakers

• Kyle Ferchen, Cincinnati Children’s Hosp. Med. Ctr., Th2 immune responses induced by helminth infection reprogram multilineage progenitors to produce successive waves of neutrophils, basophils, and eosinophils
• Alana Marie Franceski, Univ. of Alabama at Birmingham, Tet2 deficient conventional dendritic cells contribute to clonal hematopoiesis inflammation and alter immune response
• Michela Frascoli, Univ. of Massachusetts Med. Sch., Reprogramming adult hematopoietic progenitors towards fetal-restricted lymphopoiesis via Cbfb2 gene dosage
• Mohamed Khass, Univ. of Alabama at Birmingham, The human preBCR uses CDR-H3 amino acid composition to control early B cell selection and prevent oncogenesis
• Baobao Song, incinnati Children’s Hosp. Med. Ctr., Live bacterial ligands universally regulate mTOR activity but are not essential for homeostatic innate immunity
• Diego A. Lopez, Univ. of Utah Sch. of Med., MIA-reprogramed ILC2s promote enhanced lung allergic inflammation in offspring postnatally and into adulthood
• Anna F. Carey, Univ. of Minnesota, B1 B cells contribute to inflammation and metabolic dysfunction in aged adipose tissue during endotoxemia
• Eshana Mukhopadhyay, Univ. of Cincinnati Col. of Med., The DEAD box RNA helicase DDX3X is required in natural killer cells

Hyper Airways

Chairs

• Amanda Poholek, Univ. of Pittsburgh
• Henrique Borges da Silva, Mayo Clin.

Speakers

• Rama Krishna Gurram, NHLBI, NIH, TSLP acts on Tregs to limit effector Th2 cell generation during type 2 immune responses
• Ae-Kyung Yi, Univ. of Tennessee Hlth. Sci. Ctr., Deletion of protein kinase D1 in myeloid lineage cells suppresses development of IFNγ⁺IL-17A⁺ CD4 T cells and ameliorates hypersensitivity pneumonitis
• Yibo Zheng, Tsinghua Univ., China, Identifying the expression and function of Blimp-1 in ILC2s in allergic asthma
• Jheng-Syuan Shao , Academia Sinica, Taiwan, c-Kit signaling modulated group 3 innate lymphoid cell functions in mouse neutrophilic asthma model
• Jeffrey C. Bloodworth, Indiana Univ. Sch. of Med., Lung microbial dysbiosis during early life promotes predisposition to allergic asthma
• Djalma de Souza Lima Jr., NIAID, NIH, Endogenous retrovirus reactivation promotes allergic inflammation
• Caio Loureiro Salgado, Inst. of Biomed. Sci., Univ. of São Paulo, Oral exposure to Escherichia coli toxin protects against lung allergen-induced inflammation
• Jorge E. Gomez Medellin, Univ. of Chicago, Prophylactic and therapeutic use of synthetically glycosylated antigens to limit allergic airway disease

Immunity to SARS-CoV-2

Chairs

• Bronwyn Gunn, Paul G. Allen Sch. of Global Hlth., Washington State Univ.
• Steven Varga, St. Jude Children's Res. Hosp.

Speakers

• Wei Qian, Univ. of Virginia, Longitudinal analysis reveals age-dependent immune responses to SARS-CoV-2 infection in a mouse model
• Abigail Solstad, Ohio State Univ. Col. of Med., Interferon-lambda accelerates viral clearance and regulates CD8⁺ T cells immunity in a murine model of SARS-CoV-2 infection
• Christine Nelson, NIH, IL-10 promotes tissue-resident memory T cells (T_RM) in the respiratory tract during SARS-CoV-2 infection in rhesus macaques
• Fei Gao, Stanford Univ. Sch. of Med., Robust T cell responses to the Pfizer/BioNTech vaccine compared to infection and evidence of attenuated CD8⁺ T cell responses due to COVID-19
• Megan A. Files, Univ. of Washington Sch. of Med., SARS-CoV-2 seroreversion is associated with a decrease in T cell functionality in children
• Matthew R. Pugh, Univ. of Birmingham, United Kingdom, Multi-omic spatial profiling in COVID-19 lung revels temporal evolution of the disease and novel collagen VI biomarker for outcome
• Sinem Ulusan, Paul G. Allen Sch. of Global Hlth., Washington State Univ., Cross-reactive seasonal coronavirus antibody responses contribute to antibody-mediated effector functions against SARS-CoV-2 in individuals in Kenya

Responses: Differentiation, Age, Exhaustion, and Memory

Chairs

• Jie Sun, Univ. of Virginia
• Weishan Huang, Sch. of Vet. Med., Louisiana State Univ.

Speakers

• Daniel Thiele, Monash Univ., Australia, Exploring the role of T_VM cells in age-related CD8⁺ T cell dysfunction through ATAC-seq and RNA-seq analysis
• Stephen John Turner, Monash Univ., Australia, BMI-1 repression of the CD8⁺ T cell effector program is essential for memory formation
• Michael C. McGee, Louisiana State Univ., TCF-1 dictates lung tissue resident helper T cell and memory B cell development during flu
• Yongyong Cui, Feinberg Sch. of Med., Northwestern Univ., MHC Ib-restricted T Cells Generate the Dominant Memory T Cell Response in Early Stages of Mycobacterium tuberculosis Infection
• Gunjan Kak, Univ. of Nebraska Med. Ctr., An essential role for CD4⁺ T cells during Staphylococcus aureus craniotomy infection
• Surojit Sarkar, Univ. of Washington Sch. of Med., Programming of checkpoint blockade responsive exhausted T cells by rheostatic IL-2 signals during priming by dendritic cells
• Giuseppe Sciume, Sapienza Univ. of Rome, Divergent roles for STAT4 in shaping effector differentiation of ILC1 and NK cells during gut inflammation
• Jose C. Crispin, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico, Failed induction of lncRNA NeST underlies deficient IFN-γ production by CD8 T cells in sepsis survivors

Environmental Influences: Sex, Pregnancy, Diet, and T Cells

Chairs

• Robert B. Lochhead, Med. Col. of Wisconsin
• Wendy Goodman, Case Western Reserve Univ. Sch. of Med.

Speakers

• Sarah K. McNeer, Case Western Reserve Univ. Sch. of Med., Murine CD4⁺ T cells exhibit sexually dimorphic responses to estrogen signaling
• Farha J. Mithila, Brown Univ., Effect of estrogen signaling in CD8 T cell mediated antiviral response
• Jing Li, Stanford Univ. Sch. of Med., Regulation of fetal tolerance by KIR⁺ regulatory CD8⁺ T cells in human pregnancy
• Hee Kap Kang, Ann & Robert H. Lurie Children's Hosp. of Chicago and Northwestern Univ., Prenatally Educated Friendly NK Cells regulate Allo-specific T cell Responses through expansion of Foxp3⁺CD4⁺Treg Cells and suppression of Type 1 and 17 CD8⁺T cell responses
• Megan Mulholland, Lund Univ.. Sweden, PD1 blockade promotes IFN-γ production by progenitor exhausted PD1-expressing T cells in atherosclerotic plaques
• Brenna Appleton, Vanderbilt Univ., Oxidized phospholipid oxPAPC induces a dysfunctional Th1-like phenotype in regulatory T cells
• Haiguang Wang, Univ. of Minnesota Med. Sch., T follicular helper cells restrain obesity-related metabolic disease by damping intestinal inflammation
• Andrew R. Patterson, Vanderbilt Univ. Med. Ctr., Overlapping Mendelian disorders of immunity and metabolism shape CD4⁺ T cell immunometabolism

Immune Checkpoint Blockade and CAR T/T Cell Therapy for Cancer Treatment

Chairs

• Mark Rubenstein, Ohio State Univ.
• Michelle Krogsgaard, New York Univ. Sch. of Med.

Speakers

• Benjamin C. Angeles, NCI, NIH, Generation of novel anti-tumor chimeric antigen receptors incorporating downstream T- cell signaling proteins
• Shubhabrata Majumdar, Univ. of Utah, CD3ζ ITAM diversity determines chimeric antigen receptor signaling and function
• Alfredo Amador, Mem. Sloan Kettering Cancer Ctr., CAR T-cell intrinsic PD1 Dominant Negative Receptor (PD1DNR) functions by both cell-intrinsic and extrinsic mechanisms
• Justin M. Mirazee, NCI, NIH, Hinging on success: leveraging the power of CAR T cell therapy through in-silico modeling of hinge length and epitope location
• Shannon Lynn Ferry, Geisel Sch. of Medicine, Dartmouth Col., Super2-IL-33 armored CAR T cells reshape the tumor microenvironment to universally suppress solid tumor growth
• Nathaniel Oberholtzer, Med. Univ. of South Carolina, Modulating the ER and Golgi stress response in T cells with hydrogen sulfide signaling to enhance the anti-tumor immune response
• Satomi Ando, Cincinnati Children's Hosp. Med. Ctr., mTOR signals regulate T cell exhaustion and T cell responses during PD-1 targeted immunotherapy in chronic viral infection
• Theodore Papadopoulos, Lady Davis Inst., Canada, Examining methotrexate's safety and efficacy in combination with immune checkpoint inhibitors to control immune related inflammatory arthritis in cancer

Immune Mechanisms of Human Disease: Autoimmunity

Chairs

• Kristine Kuhn, Univ. of Colorado Anschutz Med. Campus
• Xin Luo, Virginia Tech

Speakers

• Michael A. Paley, Washington Univ. Sch. of Med., Single cell sequencing suggests mucosal origins of T cells in HLA-B27-associated inflammation
• Tejpal Gill, Oregon Hlth. and Sci. Univ., Cellular indexing of transcriptomes and epitopes by sequencing (CITE-Seq) of peripheral blood to dissect the effect of different spondyloarthropathies
• Melissa G. Lechner, David Geffen Sch. of Med., Univ. of California, Los Angeles, Clonally-expanded, thyrotoxic autoimmune mediator CD8⁺ T cells driven by IL21 contribute to checkpoint inhibitor thyroiditis
• Sarthak Gupta, NIAMS. NIH, Inhibition of Janus Kinase pathway corrects IFN-driven inflammation and epithelial dysfunction in Sjögren's disease
• Razan M. Alajoleen, Col. of Vet. Medicine, Virginia Tech, Single-cell RNA sequencing reveals disease stage-dependent transcriptomic profiles of regulatory B cells in systemic upus erythematosus
• Rosah May Palermo Payumo, Res. Inst. and Hosp. of Natl. Cancer Ctr., South Korea, In vitro generation of disease-specific autoantibodies produced by B cells from patients with NMOSD and MOGAD
• Kalpana Manthiram, NIAID, NIH, Trisomy 8-associated autoinflammatory disease (TRIAD) is characterized by dysregulated myeloid cells
• Hans Dooms, Natl. Jewish Hlth., T cell subsets in systemic sclerosis patients show features of exhaustion and reduced anti-fibrotic activities

Chairs

• George Dubyak, Case Western Reserve Univ.
• Amanda Jamieson, Brown Univ.

Speakers

• Jonathan R. Brestoff, Washington Univ. Sch. of Med. in St. Louis, Intercellular mitochondria transfer rescues aerobic respiration in metabolically compromised macrophages in vitro and in vivo
• Gabriela Pessenda, NIAID, NIH, Kupffer cells heterogeneity and replacement by monocyte-derived KCs contributes to visceral leishmaniasis resistance
• Jessica L. Annis, Univ. of Virginia Sch. of Med., Regulation of myeloid cells and inflammation marks increased susceptibility in a genetic model of acute viral infection-induced tissue damage
• Grozdan Cvijetic, NIDCR, NIH, Notch2 deficiency generates functionally impaired cDCs and macrophages that correlates with intestinal dysbiosis and low-grade inflammation
• Kristen A. Byrne, ARS, USDA, Intravenous BCG induction of innate memory in young pigs
• Montserrat Carolina Arreguin, Univ. of Pennsylvania, Perelman Sch. of Med., Dynamics of immune cells in the fetal brain upon viral inflammation
• Meredith Crane, Brown Univ., IL-1 signaling directs the prioritization of inflammatory sites in a model of post-operative pulmonary infection
• Joshua T. Mattila, Univ. of Pittsburgh Sch. of Public Hlth., Macrophages and neutrophils in lymph node granulomas from Mycobacterium tuberculosis-infected macaques have immunoregulatory phenotypes

Innate Immunity, Infection, and Autoimmunity

Chairs

• Heth R. Turnquist, Univ. of Pittsburgh Sch. of Med.
• Timothy O'Sullivan, Univ. of California, Los Angeles

Speakers

• Joey Li, David Geffen Sch. of Med., Univ. of California, Los Angeles, MEF2C is a critical regulator of human NK cell metabolism
• Dustin Hancks, Univ. of Texas Southwestern Med. Ctr., Secondary cues alter ISG protein repertoires to unlock antiviral subprograms triggered by interferons
• Liang Chi, NIAID, NIH, Androgen signaling shapes the sexual differences of skin immunity by regulating ILC2 and dendritic cells
• Christopher J. Genito, Univ. of North Carolina at Chapel Hill, Impaired mTOR Signaling Causes Immune Suppression in Diabetes
• Xiaomin Yao, New York Univ. Grossman Sch. of Med., Heterozygosity for Crohn's Disease Risk Allele of Atg16L1 Protects from Salmonella Infection
• Devashis Mukherjee, Case Western Reserve Univ. Sch. of Med., Myeloid-KLF2 knockout neonatal mice experience mortality from lipopolysaccharide in an age-dependent and cell-specific manner
• Carmen Mathmann, Frazer Inst., Univ. of Queensland, Spatiotemporal regulation of rp105 subcellular localization shapes endosomal tlr4 signaling
• Jordan Warunek, Univ. of Pittsburgh Sch. of Med., Macrophage recognition of non-self MHCI triggers signaling pathways directing differentiation and initiating tissue repair

Metabolic and Dietary Strategies to Treat Immune Diseases

Chairs

• Hui-Chen Hsu, Univ. of Alabama at Birmingham
• Laura Piccio, Washington Univ. in St. Louis

Speakers

• John D. Mountz, Univ. of Alabama at Birmingham, IL-4 acts through aryl hydrocarbon receptor to antagonize TLR7 induced double negative 2 B cells in lupus
• Longhuan Ma, Univ. of Texas Hlth. Sci. Ctr. San Antonio, Ruminococcus gnavus is a pathobiont expanded by genetic susceptibility and dietary tryptophan in a lupus-prone mouse model
• Brenda Seymour, Univ. of Colorado Anschutz Med. Campus, Bacterial catabolism of tryptophan to indole is required to induce collagen induced arthritis via the IL23/Th17 axis
• Xiang Lin, The Univ. of Hong Kong, Tryptophan diet promotes myeloid-derived suppressor cell response via aryl hydrocarbon receptor in Sjögren's syndrome
• Miguel Tolentino, Washington Univ. in St Louis Sch. of Med., Randomized clinical trial of intermittent calorie restriction in people with multiple sclerosis: effects on immunometabolic and cognitive measures
• Yuelin Zhong, Boston Children's Hosp., Targeting glutamine metabolism mitigates Foxp3-deficiency mediated disease
• Mohammad Nematullah, Henry Ford Health, Immunoresponsive Gene 1: an important regulator of autoreactive CD4⁺ T Cells in mouse model of multiple sclerosis
• Kim Maree O'Sullivan, Monash Univ., Australia, Resistant starch supplementation alters the gut microbial consortium and attenuates kidney inflammation in an experimental model of autoimmune vasculitis

Regulation of Protective T Cell Immunity in Cancer

Chairs

• Khashayarsha Khazaie, Mayo Clin.
• Troy Randall, Univ. of Alabama at Birmingham

Speakers

• Zoe C. Schmiechen, Univ. of Minnesota, Abrogating regulatory T cells overcomes tumor-specific T cell exhaustion and prevents metastatic pancreatic cancer
• David J. Friedman, Mayo Clin., The molecular underpinnings of Treg plasticity in cancer
• Qiyuan Yang, Salk Inst. for Biological Studies, PPARd restricts intratumoral Treg function through negatively regulating the CIITA-MHCII axis
• Marie Boutet, Albert Einstein Col. of Med., Loss of the MLL3 tumor suppressor accelerates breast tumor onset via HIF1a-induced CCL2-mediated recruitment of CCR2⁺ regulatory T cells
• Maria A. Cardenas, Emory Univ., Stem-like CD4 T differentiation controls CD8 T cell immunity or tolerance in cancer
• Lizmarie Garcia-Rivera, Salk Inst. for Biological Studies, Spatial profiling of glioblastoma microenvironments and response to immunotherapy
• Sweta Desai, Univ. of Alabama at Birmingham, Characterizing the role of IL-33/ST2 axis in regulating anti-tumor function by CD8 T cells during tumor metastasis in the omentum
• Katayoun Ayasoufi, Mayo Clin., Circulating cell-free DNA directly inhibits T cell function and contributes to peripheral immunosuppression in experimental GBM

The Tumor Microenvironment: Mechanisms of Tumor Growth and Metastasis

Chairs

• Melanie R. Rutkowski, Univ. of Virginia
• Virginia Shapiro, Mayo Clin.

Speakers

• Seyedehfatemeh Razavipour, Georgetown Univ., C-terminally phosphorylated p27 drives cancer-promoting inflammation 1
• Carlos Oscar Ontiveros, Univ. of Texas Hlth. Sci. Ctr. at San Antonio, Melanocyte PDL1 promotes early tumor progression in a novel autochthonous NRAS-mutant melanoma model
• Geoffrey R. Parriott, Univ. of Chicago, Determining mechanisms of T cell leukemogenesis using E2A^-/- mice
• Yin Chen, Mayo Clinic Grad. Sch. of Biomed. Sci., ST8Sia6 sialylates CD44 in cancer cells to generate ligands for inhibitory Siglecs
• Hinda Najem, Northwestern Univ., Immune spatial differences between short and long-term surviving glioblastoma patients
• Ashley M. Mello, Univ. of Michigan Med. Sch., Hypoxia promotes inflammatory fibroblast formation in pancreatic cancer
• Ashley N. Pearson, Univ. of Michigan Med. Sch., Liver metastases potentiate cancer progression