Sunday, May 14, 2023

• The Registration Desk is to just your right as you enter Exhibit Hall D.
• The AAI Member Lounge is in the front left corner of Exhibit Hall D.
• The Information Desk is just to your left as you enter Exhibit Hall D.

All speakers are required to go to the Speaker Ready Room at least 4 hours prior to the start of their session to ensure their presentation is properly uploaded and displays correctly. For details, visit the IMMUNOLOGY2023™ Podium Presentation Guidelines page.

Child care will be provided by KiddieCorp at no cost to attendees. For details, visit the IMMUNOLOGY2023™ Child Care page.

AAI staff will be available at the AAI Staff Office to assist attendees during the meeting.

For a fee of $5/bag, luggage storage will be available at the convention center. (AAI is not responsible for lost, stolen, or damaged belongings.)

Engineering at the Interface of Immunology and Immunotherapy

Chairs

• Jeffrey A. Hubbell, Univ. of Chicago
• Susan N. Thomas, Georgia Tech

Speakers

• Jeffrey A. Hubbell, Univ. of Chicago, Engineering cytokines to modulate regiospecific function
• Evan A. Scott, Northwestern Univ., Engineering synthetic nanocarriers for targeted immune modulation
• Jennifer H. Elisseeff, Johns Hopkins Univ., Engineering immune-stromal crosstalk regulating tissue structure
• Sai T. Reddy, Swiss Fed. Inst. of Tech., Zurich, Synthetic coevolution of neutralizing antibodies and SARS-CoV-2
• James J. Moon, Univ. of Michigan, Engineering strategies to modulate the gut microbiome and immune system
• Susan N. Thomas, Georgia Tech, Engineered lymph node drug delivery and disease modeling technologies enable next-generation approaches in cancer immunotherapy

Environmental Drivers of Myeloid Cells

Chairs

• Jessica A. Hamerman, Benaroya Res. Inst.
• P’ng Loke, NIAID, NIH

Speakers

• Jessica A. Hamerman, Benaroya Res. Inst., Monocyte differentiation during inflammation
• P’ng Loke, NIAID, NIH, Helminth exposure protects against murine SARS-CoV-2 infection through macrophage dependent T cell activation
• Paul Kubes, Univ. of Calgary, Loss of resident macrophage identity induced by local environmental changes
• Mark B. Headley II, Fred Hutch Cancer Res. Ctr., Immunosurveillance of the lung by specialized dendritic cell populations
• Amariliz Rivera, Rutgers New Jersey Med. Sch., Novel insights on the role of interferons as regulators of pulmonary antifungal immunity

Cellular Responses to Microbial, Parasitic, and Fungal Infection

Chair

• Lee Ann Garrett-Sinha, SUNY Buffalo

Speakers

• Fei Chen, Rutgers New Jersey Med. Sch., Neutrophils show distinct patterns of activation in the context of infection with different pathogens
• Elizabeth M. Hammond, Univ. of California, Davis, Ineffective polarization characterizes CD4 T cell responses to persistent Borrelia burgdorferi infection
• Komi Gbedande, Rutgers New Jersey Med. Sch., IL-21 from IFN-g⁺IL-21⁺ hybrid T cells promotes germinal center B cell proliferation
• Steven Tan, Walter Reed Army Inst. of Res., Plasmodium falciparum mRNA liver stage antigens induce antibody and liver CD8 TRM and CD8 T_E cell responses in mice
• Erin Fowler, Ohio State Univ. Col. of Med., Hypoxia promotes cytolytic activity of CD8 T cells and pathogenesis in cutaneous leishmaniasis
• Nicole Maloney Belle, Univ. of Pennsylvania Hlth. System, Trefoil factor 3 via Lingo2 restrains type-1 responses during GI nematode infection
• Raj Priya, Indiana Univ. Sch. of Med., Borrelia burgdorferi c-di-AMP induces type I IFN response in macrophage through the activation of STING signaling pathway
• Jian-Da Lin, Natl. Taiwan Univ., Single-cell multi-omic analysis reveals serum amyloid A3 restrains alternative activations in macrophages derived from different origins

Lymphocyte Fate, Maintenance, and Activation

Chairs

• Barbara Kee, Univ. of Chicago
• Mary Philip, Vanderbilt Univ. Med. Ctr.

Speakers

• Yi Ding, NCI, NIH, Two developmental pathways generate functionally distinct populations of natural killer cells
• Roxroy C. Morgan, Univ. of Chicago, Ets1 represses a T-bet dependent migration program and stabilizes the iNKT1 adhesome
• Sandip Ashok Sonar, Univ. Arizona, The age-related changes in lymph node stromal cells underlie defects in peripheral T cell maintenance and immune function decline in old mice
• Daniel Thomas McManus, Emory Univ., Early generation and anatomical commitment of stem-like CD8 T cells
• Natalie Favret, Vanderbilt Univ. Med. Ctr., TCR signaling dynamically regulates TCF1 expression and effector differentiation
• Taylor Heim, New York Univ. Sch. of Med., Resident memory T cells in the lymph node balance localized and systemic protection
• Leena Abdullah, Geisel Sch. of Med., Dartmouth Col., Dynamic single cell lineage recording of endogenous viral specific CD8 T cells reveals multiple potential cell fate pathways
• Alicia Virginia Aguilar, Case Western Reserve Univ. Sch. of Med., Decreased memory persistence in Piezo1 deficient T cells ameliorates disease progression in autoimmune mouse models

Pathogenesis to SARS-CoV-2 Infection

Chairs

• Pablo Penaloza-MacMaster, Northwestern Univ. Feinberg Sch. of Med.
• Robin Stephens, Rutgers New Jersey Med. Sch.

Speakers

• Solomon Taye Sima, Rutgers Univ. New Jersey Med. Sch., Immunoregulatory roles of TGF-β and IL-4 during mouse-adapted SARS-CoV-2 infection
• Shailendra Kumar Verma, La Jolla Inst. for Immunology, SARS-CoV-2 Delta requires human ACE2 but not human TMPRSS2 to infect mice and elicits greater lung injury and adaptive immune response than Omicron in human ACE2 knock-in mice
• Vadim I. Pivniouk, Univ. of Arizona, IL-13 protects epithelial cells from SARS-CoV-2 infection by inhibiting early ACE2-mediated events
• Emiko Urano, Natl. Inst. of Biomed. Innovation, Hlth. and Nutrition, Japan, Understanding of SARS-CoV-2 pathogenicity in COVID-19 cynomolgus macaque model and consideration of its reinfection
• Paoline Laurent, Hosp. for Special Surgery, Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19
• Fernanda Ana-Sosa-Batiz, La Jolla Inst. for Immunology, A new mouse model expressing human ACE2, TMPRSS2, and FCGRT for evaluating human antibody responses to SARS-CoV-2
• Lisa K. Ryan, Univ. of Louisville, SARS-CoV2 decreases human beta-defensin-1 and FoxI1 in the oral cavity without affecting CFTR

Generously supported by JDRF

T Cell Responses in Autotimmune Disease

Chairs

• Amy Lovett-Racke, Ohio State Univ. Med. Ctr.
• Brian Evavold, Univ. of Utah

Speakers

• Zemin Zhou, Univ. of Utah, DM functions differently in thymic antigen presentation cell subsets in development of autoreactive CD4⁺ T cells
• John P. Driver, Univ. of Missouri, Columbia, Deletion of Vβ3⁺ CD4⁺ T-cells by endogenous mouse mammary tumor virus 3 prevents type 1 diabetes induction by autoreactive CD8⁺ T-cells
• Sanya Arshad, Univ. of Pittsburgh, Identification of T cell autoantigens in a mouse model of lupus nephritis
• Christina N. Rau, Ohio State Univ. Wexner Med. Ctr., miRNAs targeting TGFβ-signaling disrupt Treg development and function in CNS autoimmunity
• Samuel J. Connell, Univ. of Iowa, CD4 T cells from mice with alopecia areata express an effector like phenotype and can transfer disease
• Peter A. Morawski, Benaroya Res. Inst., Cutaneous T cells promote distinct outcomes in human skin structural cells associated with inflammatory disease
• Sydney B. Crotts, Mayo Clin. Grad. Sch. of BioMed. Sci., The role of ST8Sia6 in braking inflammation in inflammatory bowel disease
• Ivy L. Debreceni, Univ. of Iowa, IL-27 promotes pathogenic Tfh-like CD4 effectors and exhausted-like CD8 T cells in a mouse model of Sjögren's

Sponsored by the AAI Education Committee and ImmunoHorizons

Chairs

• Nicholas A. Pullen, Univ. of Northern Colorado, AAI Education Committee Chair
• Heather A. Bruns, Univ. of Alabama at Birmingham, ImmunoHorizons Editor

Mentors:

• Katayoun Ayasoufi, Mayo Clin.
• Aimee Bernard, Univ. of Colorado
• Bonnie Blomberg, Univ. of Miami, Miller Sch. of Med.
• Deborah Brown, Trudeau Inst.
• Melanie Gubbels Bupp, Randolph-Macon Col.
• Farhan Cyprian, Qatar Univ., Qatar
• Benjamin Enslow, Univ. of Texas Hlth. Sci. Ctr., San Antonio
• Beth Garvy, Univ. of Kentucky, Chandler Med. Ctr.
• Maria Guerrero-Plata, Louisiana State Univ.
• Jeniffer Hernandez, Keck Grad. Inst.
• Stephanie James, Regis Univ.
• Liliana Lamperti, Univ. of Concepcion, Chile
• Estefania Nova-Lamperti, Univ. of Concepcion, Chile
• Reinhard Obst, Univ. of Munich, Germany
• Robin Orozco, Univ. of Kansas
• Sumali Pandey, Minnesota State Univ.
• Fernanda Rosa, Texas Tech Univ.
• Sophia Sarafova, Davidson Col.
• Jastaranpreet Singh, Univ. of Toronto, Canada
• Michelle Swanson-Mungerson, Midwestern Univ., Chicago Col. of Osteopathic Med.
• Julie Swartzendruber, Midwestern Univ.
• Michael Volin, Midwestern Univ.

Are you interested in immunology education? Join the editors of ImmunoHorizons and the AAI Education Committee for a networking event for current and future immunology educators! The first part of this session will be short one-on-one meetings, where you’ll have the opportunity to meet others with an interest in immunology education. Then attendees can continue their conversations in a relaxed setting over coffee. All are welcome! Scientists and trainees of all backgrounds are encouraged to attend.

Registration Fee: $15 (includes coffee)

Recipients of Trainee Abstract and Trainee Poster Awards may pick up their award checks at the Information Desk, just inside Exhibit Hall D.

Bring your colleagues, mentors, collaborators, or friends to record your stories, shared experiences, and thoughts on how COVID-19 impacted your research, career, and life.

Please note that the booth will be closed every day from 12:00 PM – 1:00 PM for lunch.

The Exhibit Hall at IMMUNOLOGY2023™ brings attendees and exhibitors together for three event-filled days of booth displays of products and services and educational workshops hosted by exhibiting companies. For details, visit the IMMUNOLOGY2023™ Exhibitors page and the IMMUNOLOGY2023™ Exhibitor Workshops page.

NIH program and review staff will be available in the NIH Grant Review and Funding Information Room for individual conversations and consultations. The schedule will be posted below, on the IMMUNOLOGY2023™ Careers page and on-site to show specific times staff members will be available to answer questions about the scientific review process, grant/fellowship opportunities, and NIH institute-specific interests. Consultations will be available on a drop-in basis. No appointments are necessary.

Schedule for Sunday, May 14

• 9:30 AM – 10:30 AM: Mike Humble, NIEHS; Anuja Mathew, NIAID;
  Hiten Chand, NIAID
• 10:30 AM – 11:30 AM: Debbie Hodge, NIAID; Scott Jakes, NIAID
• 11:30 AM – 12:30 PM: Yin Liu, NCI; Joy Liu, NIAID
• 12:30 PM – 1:30 PM: Mercy PrabhuDas, NIAID; Xinrui Li, CSR;
  Vanitha Raman, NIAID
• 1:30 PM – 2:30 PM: Conrad Mallia, NIAID; Tera Bounds, CSR;
  Su-Yau Mao, NIAMS
• 2:30 PM – 3:30 PM: Courtney Pinard, NIMH; Kentner Singleton, NIAID; Heiyoung Park, NIAMS
• 3:30 PM – 4:30 PM: Joy Liu, NIAID; Michael Opata, NIAID; Jim Snyder, NIAID

Making Custom MHC Tetramers at the Lab Bench Using the QuickSwitch Kit

Presenter

• Yuri Poluektov, Ph.D., Lab Scientist, Research and Development

In order to fully understand and characterize T cell populations, many MHCs with multiple different peptide combinations need to be screened and tested. A novel technology simplifies the process of screening numerous MHC-peptide combinations to simplify T cell analysis and make the assay cost efficient. In this workshop. we review procedures involved in using the QuickSwitch™ kit to make a custom MHC Tetramer that can be ready to stain T cells in 4 to 18 hours. We will discuss assay workflow and quantification of the binding affinity of the tested peptide for the MHC molecule using this kit.

Comparing Tumor Killing Mechanisms of Antibody Drug Conjugates (ADC’s) with the iQue^® Flow Cytometry System

Presenters

• Kirsty McBain, Scientist
• Don Weldon, Cell Analysis Technology Expert, Product Management

Antibody drug conjugates (ADCs) marry together two types of cancer treatment, chemotherapy and immunotherapy, to create highly-specific and efficacious therapeutics. Each ADC has been designed with unique features such as the position, number and identity of the cytotoxic payload, as well as the structure of the adjoining linker. These characteristics mean that even ADCs based on the same monoclonal antibody backbone can have largely different functional profiles. We describe the use of the iQue^® Flow Cytometry Platform to profile the binding and tumor cell- killing mechanism of anti-HER2 ADCs.

Cutting Edge Research in Transplantation Tolerance, Rejection, and Infection

Chairs

• Valeria R. Mas, Univ. of Maryland Sch. of Med.
• Leonardo V. Riella, Massachusetts Gen. Hosp.

Speakers

• Keri E. Lunsford, Rutgers New Jersey Med. Sch., Liver transplant multi-omic assessment of immune frailty
• Anoma Nellore, Univ. of Alabama at Birmingham, Mucosal flu-specific B cells: insights from vaccine and ex vivo lung perfusion studies
• Mandy L. Ford, Emory Univ., Risky memory T cell subsets in transplantation
• Paolo Cravedi, Icahn Sch. of Med. at Mount Sinai, Inducing regulatory T cells for allograft survival

Immunoparasitology: Perspectives by Top Trainees, Early Career, and Established ASTMH Researchers

Chairs

• Robin Stephens, Rutgers New Jersey Med. Sch.
• Azza Hussein Idris, NIAID, NIH

Speakers

• Romaniya Zayats, Univ. of Manitoba, Canada, Cellular dynamics of immune evasion during Leishmania major infection
• Kirk D. C. Jensen, Univ. of California, Merced, Regulation of humoral immunity to Toxoplasma gondii
• Azza Hussein Idris, NIAID, NIH, Antibodies for malaria prevention—a bench to bedside story
• Robin Stephens, Rutgers New Jersey Med. Sch., CD4⁺ T cell regulation of immunity to plasmodium parasites

Sponsored by the AAI Education Committee
Generously supported by BD Biosciences

Chair

• Kiyomi Komori, Kinevant

Panelists

• Agata Bartczak, Horizon Therapeut.
• Louise M. D'Cruz, BD Biosci.
• Ian T. Saunders, Janssen Res. and Development
• Thomas A. Wynn, Pfizer

Many opportunities exist in industry for scientists with advanced degrees. There are positions in laboratory research, program management, business development, regulatory affairs, clinical trials oversight, medical liaison, and more. This panel features scientists employed in a variety of positions in industry discussing their career paths and the skills required for success in each. Following the panel discussion, enjoy casual conversation with the speakers and other scientists from industry at a networking reception.

Developing Your Bloody Immune System

Chairs

• Christina Camell, Univ. of Minnesota
• Robert Welner, Univ. of Alabama at Birmingham

Speakers

• Kyle Ferchen, Cincinnati Children’s Hosp. Med. Ctr., Th2 immune responses induced by helminth infection reprogram multilineage progenitors to produce successive waves of neutrophils, basophils, and eosinophils
• Alana Marie Franceski, Univ. of Alabama at Birmingham, Tet2 deficient conventional dendritic cells contribute to clonal hematopoiesis inflammation and alter immune response
• Michela Frascoli, Univ. of Massachusetts Med. Sch., Reprogramming adult hematopoietic progenitors towards fetal-restricted lymphopoiesis via Cbfb2 gene dosage
• Mohamed Khass, Univ. of Alabama at Birmingham, The human preBCR uses CDR-H3 amino acid composition to control early B cell selection and prevent oncogenesis
• Baobao Song, incinnati Children’s Hosp. Med. Ctr., Live bacterial ligands universally regulate mTOR activity but are not essential for homeostatic innate immunity
• Diego A. Lopez, Univ. of Utah Sch. of Med., MIA-reprogramed ILC2s promote enhanced lung allergic inflammation in offspring postnatally and into adulthood
• Anna F. Carey, Univ. of Minnesota, B1 B cells contribute to inflammation and metabolic dysfunction in aged adipose tissue during endotoxemia
• Eshana Mukhopadhyay, Univ. of Cincinnati Col. of Med., The DEAD box RNA helicase DDX3X is required in natural killer cells

Hyper Airways

Chairs

• Amanda Poholek, Univ. of Pittsburgh
• Henrique Borges da Silva, Mayo Clin.

Speakers

• Rama Krishna Gurram, NHLBI, NIH, TSLP acts on Tregs to limit effector Th2 cell generation during type 2 immune responses
• Ae-Kyung Yi, Univ. of Tennessee Hlth. Sci. Ctr., Deletion of protein kinase D1 in myeloid lineage cells suppresses development of IFNγ⁺IL-17A⁺ CD4 T cells and ameliorates hypersensitivity pneumonitis
• Yibo Zheng, Tsinghua Univ., China, Identifying the expression and function of Blimp-1 in ILC2s in allergic asthma
• Jheng-Syuan Shao , Academia Sinica, Taiwan, c-Kit signaling modulated group 3 innate lymphoid cell functions in mouse neutrophilic asthma model
• Jeffrey C. Bloodworth, Indiana Univ. Sch. of Med., Lung microbial dysbiosis during early life promotes predisposition to allergic asthma
• Djalma de Souza Lima Jr., NIAID, NIH, Endogenous retrovirus reactivation promotes allergic inflammation
• Caio Loureiro Salgado, Inst. of Biomed. Sci., Univ. of São Paulo, Oral exposure to Escherichia coli toxin protects against lung allergen-induced inflammation
• Jorge E. Gomez Medellin, Univ. of Chicago, Prophylactic and therapeutic use of synthetically glycosylated antigens to limit allergic airway disease

Immunity to SARS-CoV-2

Chairs

• Bronwyn Gunn, Paul G. Allen Sch. of Global Hlth., Washington State Univ.
• Steven Varga, St. Jude Children's Res. Hosp.

Speakers

• Wei Qian, Univ. of Virginia, Longitudinal analysis reveals age-dependent immune responses to SARS-CoV-2 infection in a mouse model
• Abigail Solstad, Ohio State Univ. Col. of Med., Interferon-lambda accelerates viral clearance and regulates CD8⁺ T cells immunity in a murine model of SARS-CoV-2 infection
• Christine Nelson, NIH, IL-10 promotes tissue-resident memory T cells (T_RM) in the respiratory tract during SARS-CoV-2 infection in rhesus macaques
• Fei Gao, Stanford Univ. Sch. of Med., Robust T cell responses to the Pfizer/BioNTech vaccine compared to infection and evidence of attenuated CD8⁺ T cell responses due to COVID-19
• Megan A. Files, Univ. of Washington Sch. of Med., SARS-CoV-2 seroreversion is associated with a decrease in T cell functionality in children
• Matthew R. Pugh, Univ. of Birmingham, United Kingdom, Multi-omic spatial profiling in COVID-19 lung revels temporal evolution of the disease and novel collagen VI biomarker for outcome
• Sinem Ulusan, Paul G. Allen Sch. of Global Hlth., Washington State Univ., Cross-reactive seasonal coronavirus antibody responses contribute to antibody-mediated effector functions against SARS-CoV-2 in individuals in Kenya

Responses: Differentiation, Age, Exhaustion, and Memory

Chairs

• Jie Sun, Univ. of Virginia
• Weishan Huang, Sch. of Vet. Med., Louisiana State Univ.

Speakers

• Daniel Thiele, Monash Univ., Australia, Exploring the role of T_VM cells in age-related CD8⁺ T cell dysfunction through ATAC-seq and RNA-seq analysis
• Stephen John Turner, Monash Univ., Australia, BMI-1 repression of the CD8⁺ T cell effector program is essential for memory formation
• Michael C. McGee, Louisiana State Univ., TCF-1 dictates lung tissue resident helper T cell and memory B cell development during flu
• Yongyong Cui, Feinberg Sch. of Med., Northwestern Univ., MHC Ib-restricted T Cells Generate the Dominant Memory T Cell Response in Early Stages of Mycobacterium tuberculosis Infection
• Gunjan Kak, Univ. of Nebraska Med. Ctr., An essential role for CD4⁺ T cells during Staphylococcus aureus craniotomy infection
• Surojit Sarkar, Univ. of Washington Sch. of Med., Programming of checkpoint blockade responsive exhausted T cells by rheostatic IL-2 signals during priming by dendritic cells
• Giuseppe Sciume, Sapienza Univ. of Rome, Divergent roles for STAT4 in shaping effector differentiation of ILC1 and NK cells during gut inflammation
• Jose C. Crispin, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico, Failed induction of lncRNA NeST underlies deficient IFN-γ production by CD8 T cells in sepsis survivors

Streamline Your B Cell Research from Isolation to Expansion

Presenters

• Anthea Nice, Ph.D., Product Manager, Immunology
• Hitesh Arora, Ph.D., Scientist, Research and Development

Due to their essential role in the adaptive immune response, B cells continue to be a focal point for infectious disease, cancer, and autoimmune research, but isolating and generating these cells in relevant numbers continues to be a major challenge in the field. Join this workshop to learn about reagents for efficient B cell isolation and expansion. We will feature streamlined culture systems that enable feeder- and serum-free expansion of both human and mouse B cells with high yields, thus providing a complete workflow solution for B cell research.

TCR and BCR Repertoire Analysis and Other Approaches for the Discovery of Drug Targets, Resistance Mechanisms, and Biomarkers

Presenters

• Paul Diehl, Ph.D., Chief Operating Officer, Flexible and Scalable Genetic Screens for Discovery and Characterization of Novel Therapeutic Targets
• Alex Chenchik, Ph.D., President & Chief Scientific Officer, Improved Adaptive Immune Receptor Repertoire

We will introduce a number of Cellecta technologies along with relevant data for drug and biomarker discovery and validation, including CRISPR functional screening and cell tracking tools. Also introduced will be the recently -launched DriverMap™ Adaptive Immune Receptor (AIR) Profiling Assay that enables the identification of more clonotypes and their activation levels with great sensitivity and reproducibility.

Expanding Capabilities in Single-Cell RNA Sequencing

Presenter

• Anna Malinkevich, Senior Field Application Scientist

Single cell RNA-seq studies increasingly require larger sample and cell numbers, but existing technologies limit throughput. Evercode split-pool combinatorial barcoding overcomes these limitations by providing up to a million cells and 96 samples in one experiment. Learn about Evercode as well as two new additions to the Parse Biosciences single cell portfolio: Evercode TCR for immune profiling at scale and Gene Capture for targeted analysis of specific genes with 10 times less sequencing.

Sponsored by the AAI Minority Affairs Committee
Generously supported by BD Biosciences

AAI President Mark M. Davis will introduce the awardee and present the award immediately prior to Dr. Binder’s lecture.

Chair

• Tonya J. Webb, Univ. of Maryland Sch. of Med., AAI Minority Affairs Committee Chair

Speaker

Robert J. Binder
Univ. of Pittsburgh
Key pathways in immunosurveillance of cancer

The AAI Vanguard Award recognizes an underrepresented member investigator noted for significant scientific achievement and exemplary career success.

Generously supported by BD Biosciences

Frontiers of Human Immunology

Chair

• Mark M. Davis, HHMI, Stanford Univ. Sch. of Med., AAI President

Speakers

Pamela J. Bjorkman
Caltech
Mosaic RBD nanoparticles protect against diverse sarbecovirus challenges in animal models

Akiko Iwasaki
HHMI, Yale Sch. of Med.
Immune responses to SARS-CoV-2

Bali Pulendran
Stanford Univ.
Systems biological analysis of immunity to infection and vaccination

Petter Brodin
Imperial Col. London and Karolinska Inst.
Human immune system development

Presentation of AAI Excellence in Mentoring Award

AAI President Mark M. Davis and Shruti Naik, New York Univ. Grossman Sch. of Med., will introduce the awardee and present the award prior to the start of the President’s Symposium.

Chair

• Mark M. Davis, HHMI, Stanford Univ. Sch. of Med., AAI President

Award Recipient

Yasmine Belkaid
NIAID, NIH

The AAI Excellence in Mentoring Award recognizes exemplary career contributions to a future generation of scientists.

Practical Considerations for Spatial Phenotyping

Presenter

• Leticia Montoya, Ph.D., Staff Scientist, R&D, Protein & Cell Analysis

Spatialomics leverages multiplex imaging to achieve translational profiling of tissue specimens by assessing the relative spatial orientations of biological structures with RNA and protein expression in situ. While spatialomics has emerged as an important approach for classifying targets in cancer research, this complex workflow can be challenging. This presentation will provide key prerequisite considerations around reliable biomarker panel design, staining protocols , and mature data interpretation for successful spatialomics research applications.

Visit these special guests at the AAI Booth (5025) on Sunday:

• Meet the AAI Public Policy Fellows and discover why YOU should be our next Fellow
• Meet AAI Minority Affairs Committee (MAC) mebers and learn about MAC activities!
• Meet with members of the AAI Program Committee and suggest sessions for IMMUNOLOGY2024™

Fundamental Lessons Learned from the Clinic

Chairs

• Bojan Polić, Univ. of Rijeka, Croatia
• Rami Bechara, Université Paris-Saclay, France

Speakers

• Bojan Polić, Univ. of Rijeka, Croatia, Immune-endocrine regulation of blood glucose in a strong non-lethal viral infection
• Eva Martínez-Cáceres, Germans Trias i Pujol Hosp., Badalone, Spain, Cell-based tolerogenic therapies: from bench to bedside, and back
• Luke A.J. O'Neill, Trinity Col., Dublin, Ireland, Macrophage immunometabolism and the regulation of inflammation
• S. Marieke van Ham, Sanquin Res., Netherlands, Insights into human B cell differentiation upon infection and vaccination
• David C. Wraith, University of Birmingham, United Kingdom, The mechanism of antigen-specific immunotherapy of autoimmune diseases

How the Latest Advances in Immunology Inform the Field of Developmental Immunotoxicology: A Panel Discussion

This symposium will feature brief talks and a panel discussion between basic and developmental immunologists and immunotoxicologists to learn from and inform each other of new scientific paradigms, advances, and methodology in their respective fields.

Chairs

• Michael C. Humble, NIEHS, NIH
• Fenna C.M. Sillé, Johns Hopkins Univ.

Panelists

• Michael C. Humble, NIEHS, NIH, Introduction
• Anna E. Beaudin, Univ. of Utah, Contribution of fetal hematopoiesis to postnatal immune function and disease susceptibility
• Jamie C. DeWitt, East Carolina Univ., Impact of early-life exposure to per- and polyfluoroalkyl substances (PFAS) and implications for later life immune-based diseases
• Isha Khan, Michigan State Univ., An in vitro model of human hematopoiesis for developmental immunotoxicity testing
• Brian D. Rudd, Cornell Univ., Studying immune development in mice with normalized microbial exposure
• Momoko Yoshimoto-Kobayashi, Univ. of Texas Hlth. Sci. Cntr. at Houston, HSC-independent hematopoiesis in the embryo contributes to a significant part of adult immune cell
• Judith T. Zelikoff, New York Univ. Langone Health, Pulmonary immunotoxic effects of inhaled ambient particulate matter on prenatally-exposed offspring
• Fenna C.M. Sillé, Johns Hopkins Univ., Panel discussion: future outlook on alternatives to DIT testing

Environmental Influences: Sex, Pregnancy, Diet, and T Cells

Chairs

• Robert B. Lochhead, Med. Col. of Wisconsin
• Wendy Goodman, Case Western Reserve Univ. Sch. of Med.

Speakers

• Sarah K. McNeer, Case Western Reserve Univ. Sch. of Med., Murine CD4⁺ T cells exhibit sexually dimorphic responses to estrogen signaling
• Farha J. Mithila, Brown Univ., Effect of estrogen signaling in CD8 T cell mediated antiviral response
• Jing Li, Stanford Univ. Sch. of Med., Regulation of fetal tolerance by KIR⁺ regulatory CD8⁺ T cells in human pregnancy
• Hee Kap Kang, Ann & Robert H. Lurie Children's Hosp. of Chicago and Northwestern Univ., Prenatally Educated Friendly NK Cells regulate Allo-specific T cell Responses through expansion of Foxp3⁺CD4⁺Treg Cells and suppression of Type 1 and 17 CD8⁺T cell responses
• Megan Mulholland, Lund Univ.. Sweden, PD1 blockade promotes IFN-γ production by progenitor exhausted PD1-expressing T cells in atherosclerotic plaques
• Brenna Appleton, Vanderbilt Univ., Oxidized phospholipid oxPAPC induces a dysfunctional Th1-like phenotype in regulatory T cells
• Haiguang Wang, Univ. of Minnesota Med. Sch., T follicular helper cells restrain obesity-related metabolic disease by damping intestinal inflammation
• Andrew R. Patterson, Vanderbilt Univ. Med. Ctr., Overlapping Mendelian disorders of immunity and metabolism shape CD4⁺ T cell immunometabolism

Immune Checkpoint Blockade and CAR T/T Cell Therapy for Cancer Treatment

Chairs

• Mark Rubenstein, Ohio State Univ.
• Michelle Krogsgaard, New York Univ. Sch. of Med.

Speakers

• Benjamin C. Angeles, NCI, NIH, Generation of novel anti-tumor chimeric antigen receptors incorporating downstream T- cell signaling proteins
• Shubhabrata Majumdar, Univ. of Utah, CD3ζ ITAM diversity determines chimeric antigen receptor signaling and function
• Alfredo Amador, Mem. Sloan Kettering Cancer Ctr., CAR T-cell intrinsic PD1 Dominant Negative Receptor (PD1DNR) functions by both cell-intrinsic and extrinsic mechanisms
• Justin M. Mirazee, NCI, NIH, Hinging on success: leveraging the power of CAR T cell therapy through in-silico modeling of hinge length and epitope location
• Shannon Lynn Ferry, Geisel Sch. of Medicine, Dartmouth Col., Super2-IL-33 armored CAR T cells reshape the tumor microenvironment to universally suppress solid tumor growth
• Nathaniel Oberholtzer, Med. Univ. of South Carolina, Modulating the ER and Golgi stress response in T cells with hydrogen sulfide signaling to enhance the anti-tumor immune response
• Satomi Ando, Cincinnati Children's Hosp. Med. Ctr., mTOR signals regulate T cell exhaustion and T cell responses during PD-1 targeted immunotherapy in chronic viral infection
• Theodore Papadopoulos, Lady Davis Inst., Canada, Examining methotrexate's safety and efficacy in combination with immune checkpoint inhibitors to control immune related inflammatory arthritis in cancer

Immune Mechanisms of Human Disease: Autoimmunity

Chairs

• Kristine Kuhn, Univ. of Colorado Anschutz Med. Campus
• Xin Luo, Virginia Tech

Speakers

• Michael A. Paley, Washington Univ. Sch. of Med., Single cell sequencing suggests mucosal origins of T cells in HLA-B27-associated inflammation
• Tejpal Gill, Oregon Hlth. and Sci. Univ., Cellular indexing of transcriptomes and epitopes by sequencing (CITE-Seq) of peripheral blood to dissect the effect of different spondyloarthropathies
• Melissa G. Lechner, David Geffen Sch. of Med., Univ. of California, Los Angeles, Clonally-expanded, thyrotoxic autoimmune mediator CD8⁺ T cells driven by IL21 contribute to checkpoint inhibitor thyroiditis
• Sarthak Gupta, NIAMS. NIH, Inhibition of Janus Kinase pathway corrects IFN-driven inflammation and epithelial dysfunction in Sjögren's disease
• Razan M. Alajoleen, Col. of Vet. Medicine, Virginia Tech, Single-cell RNA sequencing reveals disease stage-dependent transcriptomic profiles of regulatory B cells in systemic upus erythematosus
• Rosah May Palermo Payumo, Res. Inst. and Hosp. of Natl. Cancer Ctr., South Korea, In vitro generation of disease-specific autoantibodies produced by B cells from patients with NMOSD and MOGAD
• Kalpana Manthiram, NIAID, NIH, Trisomy 8-associated autoinflammatory disease (TRIAD) is characterized by dysregulated myeloid cells
• Hans Dooms, Natl. Jewish Hlth., T cell subsets in systemic sclerosis patients show features of exhaustion and reduced anti-fibrotic activities

Chairs

• George Dubyak, Case Western Reserve Univ.
• Amanda Jamieson, Brown Univ.

Speakers

• Jonathan R. Brestoff, Washington Univ. Sch. of Med. in St. Louis, Intercellular mitochondria transfer rescues aerobic respiration in metabolically compromised macrophages in vitro and in vivo
• Gabriela Pessenda, NIAID, NIH, Kupffer cells heterogeneity and replacement by monocyte-derived KCs contributes to visceral leishmaniasis resistance
• Jessica L. Annis, Univ. of Virginia Sch. of Med., Regulation of myeloid cells and inflammation marks increased susceptibility in a genetic model of acute viral infection-induced tissue damage
• Grozdan Cvijetic, NIDCR, NIH, Notch2 deficiency generates functionally impaired cDCs and macrophages that correlates with intestinal dysbiosis and low-grade inflammation
• Kristen A. Byrne, ARS, USDA, Intravenous BCG induction of innate memory in young pigs
• Montserrat Carolina Arreguin, Univ. of Pennsylvania, Perelman Sch. of Med., Dynamics of immune cells in the fetal brain upon viral inflammation
• Meredith Crane, Brown Univ., IL-1 signaling directs the prioritization of inflammatory sites in a model of post-operative pulmonary infection
• Joshua T. Mattila, Univ. of Pittsburgh Sch. of Public Hlth., Macrophages and neutrophils in lymph node granulomas from Mycobacterium tuberculosis-infected macaques have immunoregulatory phenotypes

Innate Immunity, Infection, and Autoimmunity

Chairs

• Heth R. Turnquist, Univ. of Pittsburgh Sch. of Med.
• Timothy O'Sullivan, Univ. of California, Los Angeles

Speakers

• Joey Li, David Geffen Sch. of Med., Univ. of California, Los Angeles, MEF2C is a critical regulator of human NK cell metabolism
• Dustin Hancks, Univ. of Texas Southwestern Med. Ctr., Secondary cues alter ISG protein repertoires to unlock antiviral subprograms triggered by interferons
• Liang Chi, NIAID, NIH, Androgen signaling shapes the sexual differences of skin immunity by regulating ILC2 and dendritic cells
• Christopher J. Genito, Univ. of North Carolina at Chapel Hill, Impaired mTOR Signaling Causes Immune Suppression in Diabetes
• Xiaomin Yao, New York Univ. Grossman Sch. of Med., Heterozygosity for Crohn's Disease Risk Allele of Atg16L1 Protects from Salmonella Infection
• Devashis Mukherjee, Case Western Reserve Univ. Sch. of Med., Myeloid-KLF2 knockout neonatal mice experience mortality from lipopolysaccharide in an age-dependent and cell-specific manner
• Carmen Mathmann, Frazer Inst., Univ. of Queensland, Spatiotemporal regulation of rp105 subcellular localization shapes endosomal tlr4 signaling
• Jordan Warunek, Univ. of Pittsburgh Sch. of Med., Macrophage recognition of non-self MHCI triggers signaling pathways directing differentiation and initiating tissue repair

Metabolic and Dietary Strategies to Treat Immune Diseases

Chairs

• Hui-Chen Hsu, Univ. of Alabama at Birmingham
• Laura Piccio, Washington Univ. in St. Louis

Speakers

• John D. Mountz, Univ. of Alabama at Birmingham, IL-4 acts through aryl hydrocarbon receptor to antagonize TLR7 induced double negative 2 B cells in lupus
• Longhuan Ma, Univ. of Texas Hlth. Sci. Ctr. San Antonio, Ruminococcus gnavus is a pathobiont expanded by genetic susceptibility and dietary tryptophan in a lupus-prone mouse model
• Brenda Seymour, Univ. of Colorado Anschutz Med. Campus, Bacterial catabolism of tryptophan to indole is required to induce collagen induced arthritis via the IL23/Th17 axis
• Xiang Lin, The Univ. of Hong Kong, Tryptophan diet promotes myeloid-derived suppressor cell response via aryl hydrocarbon receptor in Sjögren's syndrome
• Miguel Tolentino, Washington Univ. in St Louis Sch. of Med., Randomized clinical trial of intermittent calorie restriction in people with multiple sclerosis: effects on immunometabolic and cognitive measures
• Yuelin Zhong, Boston Children's Hosp., Targeting glutamine metabolism mitigates Foxp3-deficiency mediated disease
• Mohammad Nematullah, Henry Ford Health, Immunoresponsive Gene 1: an important regulator of autoreactive CD4⁺ T Cells in mouse model of multiple sclerosis
• Kim Maree O'Sullivan, Monash Univ., Australia, Resistant starch supplementation alters the gut microbial consortium and attenuates kidney inflammation in an experimental model of autoimmune vasculitis

Regulation of Protective T Cell Immunity in Cancer

Chairs

• Khashayarsha Khazaie, Mayo Clin.
• Troy Randall, Univ. of Alabama at Birmingham

Speakers

• Zoe C. Schmiechen, Univ. of Minnesota, Abrogating regulatory T cells overcomes tumor-specific T cell exhaustion and prevents metastatic pancreatic cancer
• David J. Friedman, Mayo Clin., The molecular underpinnings of Treg plasticity in cancer
• Qiyuan Yang, Salk Inst. for Biological Studies, PPARd restricts intratumoral Treg function through negatively regulating the CIITA-MHCII axis
• Marie Boutet, Albert Einstein Col. of Med., Loss of the MLL3 tumor suppressor accelerates breast tumor onset via HIF1a-induced CCL2-mediated recruitment of CCR2⁺ regulatory T cells
• Maria A. Cardenas, Emory Univ., Stem-like CD4 T differentiation controls CD8 T cell immunity or tolerance in cancer
• Lizmarie Garcia-Rivera, Salk Inst. for Biological Studies, Spatial profiling of glioblastoma microenvironments and response to immunotherapy
• Sweta Desai, Univ. of Alabama at Birmingham, Characterizing the role of IL-33/ST2 axis in regulating anti-tumor function by CD8 T cells during tumor metastasis in the omentum
• Katayoun Ayasoufi, Mayo Clin., Circulating cell-free DNA directly inhibits T cell function and contributes to peripheral immunosuppression in experimental GBM

The Tumor Microenvironment: Mechanisms of Tumor Growth and Metastasis

Chairs

• Melanie R. Rutkowski, Univ. of Virginia
• Virginia Shapiro, Mayo Clin.

Speakers

• Seyedehfatemeh Razavipour, Georgetown Univ., C-terminally phosphorylated p27 drives cancer-promoting inflammation 1
• Carlos Oscar Ontiveros, Univ. of Texas Hlth. Sci. Ctr. at San Antonio, Melanocyte PDL1 promotes early tumor progression in a novel autochthonous NRAS-mutant melanoma model
• Geoffrey R. Parriott, Univ. of Chicago, Determining mechanisms of T cell leukemogenesis using E2A^-/- mice
• Yin Chen, Mayo Clinic Grad. Sch. of Biomed. Sci., ST8Sia6 sialylates CD44 in cancer cells to generate ligands for inhibitory Siglecs
• Hinda Najem, Northwestern Univ., Immune spatial differences between short and long-term surviving glioblastoma patients
• Ashley M. Mello, Univ. of Michigan Med. Sch., Hypoxia promotes inflammatory fibroblast formation in pancreatic cancer
• Ashley N. Pearson, Univ. of Michigan Med. Sch., Liver metastases potentiate cancer progression

AAI President Mark M. Davis will introduce the awardee and present the award immediately prior to Dr. Hafler’s lecture.

Chair

• Mark M. Davis, HHMI, Stanford Univ. Sch. of Med., AAI President

Award Recipient

David A. Hafler
Yale Sch. of Med.
Treg biology: insights into immunology by the study of human disease

The AAI-Steinman Award for Human Immunology Research recognizes an individual who has made significant contributions to the understanding of immune processes underlying human disease pathogenesis, prevention, or therapy.

Generously supported by BD Biosciences

Chair

• Cathryn R. Nagler, Univ. of Chicago, AAI Program Committee Chair

Speaker

Leslie J. Berg
Univ. of Colorado Sch. of Med.
Linking variations in T cell receptor signaling to changes in gene expression and T cell function

Generously supported by BioLegend

The IMMUNOLOGY2023™ Gala will be held at the National Museum of American History. Attendees will have the opportunity to view highly acclaimed exhibitions that tell the extraordinary story of the American people, including the Star-Spangled Banner; The American Presidency; First Ladies; The Price of Freedom; and America On the Move, which features objects ranging from Thomas Jefferson’s lap desk, Kermit the Frog, George Washington’s uniform, Dorothy’s ruby slippers, to the first car to cross the United States, and thousands more.*

(Badge and ticket are required. Attendance details are available during the online registration process. Attendees must be 21 years of age or older.)

*Please note that objects can rotate in and out of exhibition so we cannot guarantee that all items listed will be on display for the event.